中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2008年
5期
479-483
,共5页
李来友%许茂盛%曹志坚%王世威%CC Tchoyoson Lim
李來友%許茂盛%曹誌堅%王世威%CC Tchoyoson Lim
리래우%허무성%조지견%왕세위%CC Tchoyoson Lim
脑%磁共振成像%磁共振波谱学
腦%磁共振成像%磁共振波譜學
뇌%자공진성상%자공진파보학
Brain%Magnetic resonance imaging%Magnetic resonance spectroscopy
目的 探讨在体单体素氢质子MR波谱(1H-MRS)重复时间(TR)对定位测量脑组织代谢物绝对和相对浓度的影响.方法 正常志愿者30名采用1.5 T超导型MR成像系统行点分辨自旋回波(PRESS)序列单体素1H-MRS扫描,取左侧大脑半球顶枕部白质,体素8 cm3,TR分别为1500和5000 ms.采用线性拟合模型(LCModel)处理原始数据,测量肌酸和磷酸肌酸(tCr)、谷氨酸(Glu)、肌醇(mI)、N-乙酰天冬氨酸(NAA)、甘油磷酸胆碱(GPC)和谷氨酸和谷氨酰胺(Glx)等的绝对浓度和相对浓度,并采用配对t检验对不同TR下各代谢物的浓度进行比较.结果 大脑左顶枕部白质代谢物tCr、Clu、mI、NAA、GPC和Glx在TR为1500 ms时绝对浓度分别为(3.0±0.2)、(4.4±0.7)、(3.0±0.3)、(5.0±0.4)、(1.1±0.1)和(5.9±0.6)mmol/L;TR为5000 ms时分别为(4.2±0.4)、(5.3±0.5)、(3.7±0.5)、(6.7±0.7)、(1.4±0.1)和(6.6±0.6)mmol/L.TR为1500 ms时,Gh、mI、NAA、GPC和Glx的相对浓度分别为1.47±0.27、1.00±0.11、1.69±0.17、0.36±0.05和1.95±0.22;TR为5000 ms时分别为1.25±0.12、0.89±0.09、1.60±0.16、0.33±0.04和1.58±0.17.不同TR时,各代谢物绝对浓度和相对浓度差异均有统计学意义(P值均＜0.05).结论1H-MRS可有效地进行脐组织代谢物绝对浓度和相对浓度的测量,PRESS序列中不同的TR所获得的代谢物绝对和相对浓度均有较大差异,较短的TR可低估代谢物的绝对浓度.
目的 探討在體單體素氫質子MR波譜(1H-MRS)重複時間(TR)對定位測量腦組織代謝物絕對和相對濃度的影響.方法 正常誌願者30名採用1.5 T超導型MR成像繫統行點分辨自鏇迴波(PRESS)序列單體素1H-MRS掃描,取左側大腦半毬頂枕部白質,體素8 cm3,TR分彆為1500和5000 ms.採用線性擬閤模型(LCModel)處理原始數據,測量肌痠和燐痠肌痠(tCr)、穀氨痠(Glu)、肌醇(mI)、N-乙酰天鼕氨痠(NAA)、甘油燐痠膽堿(GPC)和穀氨痠和穀氨酰胺(Glx)等的絕對濃度和相對濃度,併採用配對t檢驗對不同TR下各代謝物的濃度進行比較.結果 大腦左頂枕部白質代謝物tCr、Clu、mI、NAA、GPC和Glx在TR為1500 ms時絕對濃度分彆為(3.0±0.2)、(4.4±0.7)、(3.0±0.3)、(5.0±0.4)、(1.1±0.1)和(5.9±0.6)mmol/L;TR為5000 ms時分彆為(4.2±0.4)、(5.3±0.5)、(3.7±0.5)、(6.7±0.7)、(1.4±0.1)和(6.6±0.6)mmol/L.TR為1500 ms時,Gh、mI、NAA、GPC和Glx的相對濃度分彆為1.47±0.27、1.00±0.11、1.69±0.17、0.36±0.05和1.95±0.22;TR為5000 ms時分彆為1.25±0.12、0.89±0.09、1.60±0.16、0.33±0.04和1.58±0.17.不同TR時,各代謝物絕對濃度和相對濃度差異均有統計學意義(P值均＜0.05).結論1H-MRS可有效地進行臍組織代謝物絕對濃度和相對濃度的測量,PRESS序列中不同的TR所穫得的代謝物絕對和相對濃度均有較大差異,較短的TR可低估代謝物的絕對濃度.
목적 탐토재체단체소경질자MR파보(1H-MRS)중복시간(TR)대정위측량뇌조직대사물절대화상대농도적영향.방법 정상지원자30명채용1.5 T초도형MR성상계통행점분변자선회파(PRESS)서렬단체소1H-MRS소묘,취좌측대뇌반구정침부백질,체소8 cm3,TR분별위1500화5000 ms.채용선성의합모형(LCModel)처리원시수거,측량기산화린산기산(tCr)、곡안산(Glu)、기순(mI)、N-을선천동안산(NAA)、감유린산담감(GPC)화곡안산화곡안선알(Glx)등적절대농도화상대농도,병채용배대t검험대불동TR하각대사물적농도진행비교.결과 대뇌좌정침부백질대사물tCr、Clu、mI、NAA、GPC화Glx재TR위1500 ms시절대농도분별위(3.0±0.2)、(4.4±0.7)、(3.0±0.3)、(5.0±0.4)、(1.1±0.1)화(5.9±0.6)mmol/L;TR위5000 ms시분별위(4.2±0.4)、(5.3±0.5)、(3.7±0.5)、(6.7±0.7)、(1.4±0.1)화(6.6±0.6)mmol/L.TR위1500 ms시,Gh、mI、NAA、GPC화Glx적상대농도분별위1.47±0.27、1.00±0.11、1.69±0.17、0.36±0.05화1.95±0.22;TR위5000 ms시분별위1.25±0.12、0.89±0.09、1.60±0.16、0.33±0.04화1.58±0.17.불동TR시,각대사물절대농도화상대농도차이균유통계학의의(P치균＜0.05).결론1H-MRS가유효지진행제조직대사물절대농도화상대농도적측량,PRESS서렬중불동적TR소획득적대사물절대화상대농도균유교대차이,교단적TR가저고대사물적절대농도.
Objective To investigate the variabihty of absolute and relative biochemical concenstrations at different repetition time(TR) in quantifying normal brain by single voxel proton MR spectroscopy.Methods Thirty normal volunteers signed informed consent were recruited for the study.Short echo time(TE=35 ms)single voxel spectroscopy of the left parieto-occipital white matter were performed on a 1.5 T MR scanner by using point-resolved selective spectroscopy(PRESS)sequence.Two spectra were obtained using the same voxel placement and acquisition parameters but at different TRs:first at TR=1500 ms then at TR=5000 ms.Raw data of spectra were processed on a commercial software Liinear combination model(LCModel)normalized to spectral date obtained from a reference phantom of known metabolite quantities.Measured metabohtes included total creatine(tCr,creatine and phosphocreatine),glutamate(Glu),myo-inositol(mI),N-acytalaspartate(NAA),glycerophosphorylcholine(GPC),glutamate and glutamine(Glx).The t test was performed by using SPSS 11.5 for windows.Results Both the absolute and relative concentrations of normal white matter were significanth different between spectra obtafined at TR=1500 ms and that at TR=5000 ms(P＜0.05).The absolute concentrations(mmol/L)at TR=1500 ms were tCr,3.0±0.2;Glu,4.4±0.7;ml,3.0±0.3;NAA,5.0±0.4;GPC,1.1±0.1:Glx,5.9±0.6;compared to concentration at TR=5000 ms,tCr,4.2±0.4;Gitu,5.3±0.5;mI.3.7±0.5;NAA,6.7±0.7;GPC,1.4±0.1;Glx,6.6±0.6;respectively.The concentrations relatively to tCr at TR=1500 ms,were Glu,1.47±0.27;mI,1.00±0.11;NAA,1.69±0.17;GPC,0.36±0.05;Glx,1.95±0.22;and relative concentrations at TR=5000 ms were Glu,1.25±0.12;mI,0.89±0.09;NAA,1.60±0.16;GPC,0.33±0.04;Glx,1.58±0.17;respectively.Conclusion Proton MR spectroscopy can accurately quantify absolute and relative concentrations of brain metabolites.Metabolites concentrations may be significant underestimated when using shorter repetition time in short TE spectroscopic study.
