中华麻醉学杂志
中華痳醉學雜誌
중화마취학잡지
CHINESE JOURNAL OF ANESTHESIOLOGY
2010年
4期
396-398
,共3页
哌啶类%体外循环%吸附
哌啶類%體外循環%吸附
고정류%체외순배%흡부
Piperidines%Extracorporeal circulation%Absorption
目的 比较希健-I型和AFFINITY(R) NT成人膜式氧合器体外循环回路对预冲液中瑞芬太尼的吸附作用.方法 实验分为3组(n=6):希健-I型成人膜式氧合器体外循环回路组(A组)、AFFINITY(R) NT成人膜式氧合器体外循环回路组(B组)和玻璃容器组(C组).将预冲液(6%羟乙基淀粉1000 ml和乳酸钠林格氏液500 ml)预冲入成人膜式氧合器体外循环装置或玻璃容器中,然后从静脉贮血器的静脉端或玻璃容器口注入瑞芬太尼,终浓度为100 ng/ml.于注入瑞芬太尼后2、5、10、15 min时,从静脉贮血器的动脉端或玻璃容器中抽取预冲液2 ml,采用气相色谱法检测瑞芬太尼的浓度.结果 三组不同时点间瑞芬太尼浓度比较差异无统计学意义(P>0.05).与C组比较,A组和B组各时点瑞芬太尼浓度下降(P<0.01);与B组比较,A组各时点瑞芬太尼浓度下降(P<0.01).结论 希健-I型和AFFINITY(R) NT成人膜式氧合器体外循环回路对瑞芬太尼均有吸附作用,前者的吸附作用大于后者.
目的 比較希健-I型和AFFINITY(R) NT成人膜式氧閤器體外循環迴路對預遲液中瑞芬太尼的吸附作用.方法 實驗分為3組(n=6):希健-I型成人膜式氧閤器體外循環迴路組(A組)、AFFINITY(R) NT成人膜式氧閤器體外循環迴路組(B組)和玻璃容器組(C組).將預遲液(6%羥乙基澱粉1000 ml和乳痠鈉林格氏液500 ml)預遲入成人膜式氧閤器體外循環裝置或玻璃容器中,然後從靜脈貯血器的靜脈耑或玻璃容器口註入瑞芬太尼,終濃度為100 ng/ml.于註入瑞芬太尼後2、5、10、15 min時,從靜脈貯血器的動脈耑或玻璃容器中抽取預遲液2 ml,採用氣相色譜法檢測瑞芬太尼的濃度.結果 三組不同時點間瑞芬太尼濃度比較差異無統計學意義(P>0.05).與C組比較,A組和B組各時點瑞芬太尼濃度下降(P<0.01);與B組比較,A組各時點瑞芬太尼濃度下降(P<0.01).結論 希健-I型和AFFINITY(R) NT成人膜式氧閤器體外循環迴路對瑞芬太尼均有吸附作用,前者的吸附作用大于後者.
목적 비교희건-I형화AFFINITY(R) NT성인막식양합기체외순배회로대예충액중서분태니적흡부작용.방법 실험분위3조(n=6):희건-I형성인막식양합기체외순배회로조(A조)、AFFINITY(R) NT성인막식양합기체외순배회로조(B조)화파리용기조(C조).장예충액(6%간을기정분1000 ml화유산납림격씨액500 ml)예충입성인막식양합기체외순배장치혹파리용기중,연후종정맥저혈기적정맥단혹파리용기구주입서분태니,종농도위100 ng/ml.우주입서분태니후2、5、10、15 min시,종정맥저혈기적동맥단혹파리용기중추취예충액2 ml,채용기상색보법검측서분태니적농도.결과 삼조불동시점간서분태니농도비교차이무통계학의의(P>0.05).여C조비교,A조화B조각시점서분태니농도하강(P<0.01);여B조비교,A조각시점서분태니농도하강(P<0.01).결론 희건-I형화AFFINITY(R) NT성인막식양합기체외순배회로대서분태니균유흡부작용,전자적흡부작용대우후자.
Objective To assess the possible sequestration of remifentanil by the extracorporeal circuit.Methods Two types of extracorporeal circuits (ECCs) were used-Xijian type I (group A)and AFFINITY(R) NT(group B),while in control group (group C) a glass container was used.The ECC and glass container were filled with priming solution (6%hydroxyethyl starch 1000 ml + lactated Ringer's solution 500 ml).Remifentanil Wag then added to the priming solution with the final concentration of 100 ng/ml.The priming solution was circulated in the closed ECC or stirred the glass container.The concentration of remifentanil in the priming solution was determined at 2,5,10 and 15 min after addition of remifentanil.Results The remifentanil concentration in the priming solution decreased by 75.1%,57.9% and 18.3%at 2 min after addition of the drug in group A,B and C respectively as compared with the baseline value.The remifentanil absorption by ECC was significantly greater in group A than in group B.There was no significant difference in remifentanil concentration at the 4 time points in each group.Conclusion ECC can absorb remifentanil.The remifentanil absorption by Xijian type I is significantly greater than that by AFFINITY(R).
