中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2012年
2期
185-188
,共4页
张丽%翟祥军%李艳萍%张卫%朱凤才%黄腾%颜丙玉%刘甲野%李立秋%龚晓红%崔富强%梁晓峰%徐爱强
張麗%翟祥軍%李豔萍%張衛%硃鳳纔%黃騰%顏丙玉%劉甲野%李立鞦%龔曉紅%崔富彊%樑曉峰%徐愛彊
장려%적상군%리염평%장위%주봉재%황등%안병옥%류갑야%리립추%공효홍%최부강%량효봉%서애강
乙型肝炎疫苗%抗体应答%早产儿%多中心研究
乙型肝炎疫苗%抗體應答%早產兒%多中心研究
을형간염역묘%항체응답%조산인%다중심연구
Hepatitis B vaccine%Antibody response%Preterm infants%Multi-center study
目的 分析早产儿和足月儿乙型肝炎(乙肝)疫苗(HepB)抗体免疫应答.方法 按照多中心研究方法,以北京、山东、江苏、广西4省(区市)为研究现场,选取按照0-1-6程序、使用5 μg重组HepB(酿酒酵母)(HepB-SC)或10 μg重组HepB(汉逊酵母)(HepB-HP)完成HepB初免的7～12月龄婴儿；以其中全部早产儿作为早产儿组,按照1∶1随机选择其中HepB种类、月龄、性别和居住地相同的足月儿作为足月儿组.对所有研究对象进行问卷调查,HepB免疫史根据接种卡确定；同时采集静脉血2 ml,使用化学发光微粒子免疫分析法检测血清HBV表面抗体(抗-HBs)；比较两组婴儿抗体应答率和抗体水平.结果 4省(区市)共调查648对婴儿.早产儿组初免无应答率、低应答率、正常应答率和高应答率分别为1.39％、8.64％、45.83％和44.14％,足月儿组分别为1.08％、9.26％、44.91％和44.75％,两组4项指标差异均无统计学意义(P＞0.05)；两组初免后抗-HBs几何平均浓度(GMT)分别为755.14和799.47 mIU/ml,差异无统计学意义(P＞0.05).多因素条件logistic回归分析显示,排除出生体重、分娩方式、胎次、产程损伤和父母乙肝病毒表面抗原状态后,是否早产与HepB抗体应答率无关(P＞0.05).结论 早产儿和足月儿HepB免后抗体应答无明显差异,可以按照相同的HepB免疫策略进行接种.
目的 分析早產兒和足月兒乙型肝炎(乙肝)疫苗(HepB)抗體免疫應答.方法 按照多中心研究方法,以北京、山東、江囌、廣西4省(區市)為研究現場,選取按照0-1-6程序、使用5 μg重組HepB(釀酒酵母)(HepB-SC)或10 μg重組HepB(漢遜酵母)(HepB-HP)完成HepB初免的7～12月齡嬰兒；以其中全部早產兒作為早產兒組,按照1∶1隨機選擇其中HepB種類、月齡、性彆和居住地相同的足月兒作為足月兒組.對所有研究對象進行問捲調查,HepB免疫史根據接種卡確定；同時採集靜脈血2 ml,使用化學髮光微粒子免疫分析法檢測血清HBV錶麵抗體(抗-HBs)；比較兩組嬰兒抗體應答率和抗體水平.結果 4省(區市)共調查648對嬰兒.早產兒組初免無應答率、低應答率、正常應答率和高應答率分彆為1.39％、8.64％、45.83％和44.14％,足月兒組分彆為1.08％、9.26％、44.91％和44.75％,兩組4項指標差異均無統計學意義(P＞0.05)；兩組初免後抗-HBs幾何平均濃度(GMT)分彆為755.14和799.47 mIU/ml,差異無統計學意義(P＞0.05).多因素條件logistic迴歸分析顯示,排除齣生體重、分娩方式、胎次、產程損傷和父母乙肝病毒錶麵抗原狀態後,是否早產與HepB抗體應答率無關(P＞0.05).結論 早產兒和足月兒HepB免後抗體應答無明顯差異,可以按照相同的HepB免疫策略進行接種.
목적 분석조산인화족월인을형간염(을간)역묘(HepB)항체면역응답.방법 안조다중심연구방법,이북경、산동、강소、엄서4성(구시)위연구현장,선취안조0-1-6정서、사용5 μg중조HepB(양주효모)(HepB-SC)혹10 μg중조HepB(한손효모)(HepB-HP)완성HepB초면적7～12월령영인；이기중전부조산인작위조산인조,안조1∶1수궤선택기중HepB충류、월령、성별화거주지상동적족월인작위족월인조.대소유연구대상진행문권조사,HepB면역사근거접충잡학정；동시채집정맥혈2 ml,사용화학발광미입자면역분석법검측혈청HBV표면항체(항-HBs)；비교량조영인항체응답솔화항체수평.결과 4성(구시)공조사648대영인.조산인조초면무응답솔、저응답솔、정상응답솔화고응답솔분별위1.39％、8.64％、45.83％화44.14％,족월인조분별위1.08％、9.26％、44.91％화44.75％,량조4항지표차이균무통계학의의(P＞0.05)；량조초면후항-HBs궤하평균농도(GMT)분별위755.14화799.47 mIU/ml,차이무통계학의의(P＞0.05).다인소조건logistic회귀분석현시,배제출생체중、분면방식、태차、산정손상화부모을간병독표면항원상태후,시부조산여HepB항체응답솔무관(P＞0.05).결론 조산인화족월인HepB면후항체응답무명현차이,가이안조상동적HepB면역책략진행접충.
Objective To compare the antibody response between preterm and full-term infants after primary immunization of hepatitis B vaccine (HepB).Methods Infants who were aged 7-12 months and had completed primary immunization with 5 μg HepB made by recombinant dexyribonucleic acid techniques in saccharomyces cerevisiae (HepB-SC) or 10 μg HepB made by recombinant dexyribonucleic acid techniques in Hansenula polymorpha (HepB-HP) on 0-1-6 schedule were investigated in four provinces (municipality) including Beijing,Shandong,Jiangsu and Guangxi of China.Among them,all preterm infants were selected to form the preterm group and the 1:1 matching full-term infants with the same month-age,gender and residence were randomly selected to form the full-term group.Their HepB history was determined by immunization certificate and all of their parents were interviewed with standard questionnaire to get their birth information.Blood samples were obtained from all anticipants and were tested for Anti-HBs by chemiluminescence microparticle immuno-assay (CMIA).Results Total anticipants were 648 pairs of infants.The rates of non-response,low-response,normal-response and high-response after the primary immunization were 1.39％,8.64％,45.83％ and 44.14％ in the preterm group,respectively.The corresponding rates were 1.08％,9.26％,44.91％ and 44.75％ in the full-term group.The above four rates did not show significant differences between the two groups (P＞0.05).The geometric mean concentrations (GMC) of anti-HBs in the pre-term and full-term group were 755.14 and 799.47 mIU/ml respectively.There was no significantly difference in the GMCs between the two groups (P＞0.05).Results from multivariable conditional logistic analysis showed that preterm was not an influencing factor to the antibody response after HepB primary immunization among newborns even after debugging the other influencing factors.Conclusion The autibody response after HepB primary immunization were similar among the preterm and full-term infants.The preterm newborns could be immunized under the same HepB immunization strategy.
