CAJ | 학술논문

[目的]探讨自荧光气管镜(AFB)在支气管肺癌早期诊断中的价值.[方法]对198例临床怀疑支气管肺癌患者采用AFB联合白光气管镜(WLB)检查的诊断结果进行回顾性分析,将病理诊断为恶性肿瘤和不典型增生定义为阳性,正常黏膜、增生、慢性炎症定义为阴性,统计AFB与WLB镜下异常表现及病理结果,比较其对早期肺癌诊断的敏感度.[结果]198例中AFB表现异常者186例,WLB表现异常者133例,160例病理阳性结果中癌变黏膜156例,重度不典型增生4例.AFB发现异常病理证实癌变者156例,假阳性30例,敏感性97.5％,假阳性率16.1％,WLB发现异常病理证实者128例,假阳性5例,敏感性80.0％,假阳性率3.7％,两者在敏感性和假阳性率的差异均有统计学意义(P＜0.05).[结论]对于支气管内癌前病变和早期肺癌的定位诊断,AFB检查比WIB更加敏感.
[목적]탐토자형광기관경(AFB)재지기관폐암조기진단중적개치.[방법]대198례림상부의지기관폐암환자채용AFB연합백광기관경(WLB)검사적진단결과진행회고성분석,장병리진단위악성종류화불전형증생정의위양성,정상점막、증생、만성염증정의위음성,통계AFB여WLB경하이상표현급병리결과,비교기대조기폐암진단적민감도.[결과]198례중AFB표현이상자186례,WLB표현이상자133례,160례병리양성결과중암변점막156례,중도불전형증생4례.AFB발현이상병리증실암변자156례,가양성30례,민감성97.5％,가양성솔16.1％,WLB발현이상병리증실자128례,가양성5례,민감성80.0％,가양성솔3.7％,량자재민감성화가양성솔적차이균유통계학의의(P＜0.05).[결론]대우지기관내암전병변화조기폐암적정위진단,AFB검사비WIB경가민감.
Objectives To evaluate the benefit of using autofluorescence bronchoscopy(AFB)for the detection and localization of early invasive lung cancer.Methods AFB and white light bronchoscopy (WLB)were performed on 198 cases of suspected lung cancer,and the relative sensitivity of WLB plus AFB compared with WLB alone.Results Included 198 biopsy specimens,and 160 were classified as positive by pathology,including 156 invasive cancer and 4 severe dysplasia.The relative sensitivity to detect intraepithelial neoplasia of WLB + FLB versus WLB was 97.5％ and 80.0％ respectively,significantly (P＜0.05).Conclusion AFB was more sensitive than WLB in detecting preneoplastie bronchial changes and early lung cancer in high-risk subjects.