CAJ | 학술논문

目的:建立研究肩关节不稳的动物(兔)模型,为进行相关研究提供实验依据.方法:取6只骨骼成熟的雄性新西兰大白兔进行肩关节正常组织结构的解剖,研究手术入路.通过解剖兔的肩关节并测量其关节活动度,了解兔肩关节与人肩关节骨骼、周围肌肉组织及关节囊韧带组织的类似程度,建立兔肩关节不稳动物模型的手术入路及手术方法.另取18只兔分为2组,其中12只为实验组,均取右侧肩关节,手术切开肩胛下肌腱显露盂肱关节,并切除前下方盂缘及其相连的韧带组织,制作肩关节前方不稳模型,分别于术后6周及12周(各6只)取材;其余6只为对照组,仅切开皮肤及浅层肌肉组织,于术后12周取材.测量盂肱关节活动度及稳定性.结果:兔肩关节大体解剖与人类相类似,实验组兔关节前向稳定性明显差于对照组,所有实验组肩关节均有2度以上的前向不稳定存在.实验组兔肩关节后伸、内旋、外旋及外展活动明显受限,而对照组肩关节活动基本正常.结论:兔是建立肩关节不稳动物模型和进行相关实验研究的合适动物,本实验建立的兔肩关节前向不稳模型适用于盂肱关节前向不稳的研究.
목적:건립연구견관절불은적동물(토)모형,위진행상관연구제공실험의거.방법:취6지골격성숙적웅성신서란대백토진행견관절정상조직결구적해부,연구수술입로.통과해부토적견관절병측량기관절활동도,료해토견관절여인견관절골격、주위기육조직급관절낭인대조직적유사정도,건립토견관절불은동물모형적수술입로급수술방법.령취18지토분위2조,기중12지위실험조,균취우측견관절,수술절개견갑하기건현로우굉관절,병절제전하방우연급기상련적인대조직,제작견관절전방불은모형,분별우술후6주급12주(각6지)취재;기여6지위대조조,부절개피부급천층기육조직,우술후12주취재.측량우굉관절활동도급은정성.결과:토견관절대체해부여인류상유사,실험조토관절전향은정성명현차우대조조,소유실험조견관절균유2도이상적전향불은정존재.실험조토견관절후신、내선、외선급외전활동명현수한,이대조조견관절활동기본정상.결론:토시건립견관절불은동물모형화진행상관실험연구적합괄동물,본실험건립적토견관절전향불은모형괄용우우굉관절전향불은적연구.
Objective To establish the animal model(rabbit) of shoulder instability for providing the experimental basis of related studies.Methods shoulder joints of 6 skeletally matured New Zealand white rabbits were measured with the anatomical characteristics and joint motion range in order to determine the operative approach,the similarities of skeletal structure,surrounding muscles,joint capsule and ligaments between rabbit and human were compared.Eighteen rabbits,weighing between 2.5 and 3kg were randomized into 2 groups(experimental group 12 and control 6).In experimental group,instability model was established by means of the operation procedure as follows:the glenohumeral joint of right shoulder was exposed by cutting the subscapularis tendon,then the anteroinferior labrum and surrounding capsular ligament were excised.For control group,sham operation was performed by only curing the skin and superficial tissue,the subscapularis tendon and glenoid structures was kept intact.The specimens of 6 rabbits were harvested 6 weeks after operation.The remaining rabbits of both experimental and control groups were killed 12 weeks post the operation for specimens processing.The motion range and instability were measured in all specimens.Results The gross anatomy of shoulder ioint in rabbit is similar to human.In experimental group,the stability is showed less than control,grade 2 anterior instability was found.The motion range was restricted in all directions,such as external and internal rotation,extension and abduction compared to control group.Conclusion Rabbit is suitable to establish animal model for shoulder instability and related iniuries,the animal model which was designed by this study could provide valuable information for the research of anterior shoulder instability.