CAJ | 학술논문

目的探讨苯丙胺类兴奋剂对梅毒患者血RPR滴度及阴转率的影响.方法收集36例吸食苯丙胺类毒品的梅毒患者资料,取外周血检测RPR滴度、阴转率和免疫球蛋白水平,检测外周血单一核细胞产生IFN-γ、lL-4水平,并以44例梅毒患者和30例健康人作对照.结果试验组RPR滴度明显低于对照组(P<0.05),试验组RPR阴转率在治疗后第6、9、12个月后分别为5.56%、16.67%、52.78%,明显低于对照组(P均<0.05 o试验组免疫球蛋白1IG、IgM、IgA水平『司对照组比较差异无统计学意义(P均>0.05),试验组IFN-γ水平低于对照组(P<0.01)而IL-4水平高于正常人对照组(P<0.01).结论苯丙胺类兴奋剂可使梅毒患者细胞免疫功能进一步受损而导致梅毒患者血RPR低滴度及低阴转率.
목적 탐토분병알류흥강제대매독환자혈RPR적도급음전솔적영향.방법 수집36례흡식분병알류독품적매독환자자료,취외주혈검측RPR적도、음전솔화면역구단백수평,검측외주혈단일핵세포산생IFN-γ、lL-4수평,병이44례매독환자화30례건강인작대조.결과 시험조RPR적도명현저우대조조(P<0.05),시험조RPR음전솔재치료후제6、9、12개월후분별위5.56%、16.67%、52.78%,명현저우대조조(P균<0.05 o시험조면역구단백1IG、IgM、IgA수평『사대조조비교차이무통계학의의(P균>0.05),시험조IFN-γ수평저우대조조(P<0.01)이IL-4수평고우정상인대조조(P<0.01).결론 분병알류흥강제가사매독환자세포면역공능진일보수손이도치매독환자혈RPR저적도급저음전솔.
Objective To evaluate the influence of amphetamine-type stimulants on serum rapid plasma reagent (RPR) tiler and negative conversion rate of RPR in patients with syphilis. Methods Thirty-six patients with syphilis who took amphetamine-type stimulants (ATS) were recruited in this study together with 44 patients with syphilis who never took ATS and 30 normal human controls. Benzathine benzylpenicillin was given intramuscularly to all patients at a dose of 2 400 000 unit per week for 3 weeks. RPR and treponema pallidum particle agglutination (TPPA) assay were performed before treatment, 3, 6, 9 and 12 months after the therapy. Radioimmune assay and ncphelometry were used to detect the serum level of IgG, lgM and IgA. The capability of peripheral blood mononuclear cells (PBMCs) to product interferon-T (IFN-γ) and interleukin-4 (IL-4) was evaluated with ELISA. Results Before treatment, RPR titcr was significantly lower in the stimulant-taking group than in the non-taking group (χ2 = 14.93, P < 0.05). The negative conversion rates were 5.56%, 16.67% and 52.78% in stimulant-taking group 6, 9 and 12 months after the treatment, respectively, significantly lower than those in the control group (all P < 0.05). As for the serum level of IgG, IgM and IgA, there was no significant difference among the stimulant-taking group, non-taking group and normal control group (all P > 0.05). The capability of PBMCs to product IFN-γ was highest in the stimulant-taking group, followed by the non-taking group and normal control group (all P < 0.05). No significant difference was observed in the capability of PBMCs to produce IL-4 between the stimulant-taking group and non-taking group, but a significant increment was noted in these patients compared with the normal human controls (all P < 0.01). Conclusion Amphetamine-type stimulants could reduce serum RPR titer and negative conversion rate of RPR in patients with syphilis, likely by impairing cellular immunity of patients.