CAJ | 학술논문

目的探讨脑膜瘤99Tcm-联肼尼克酰胺(HYNIC)一奥曲肽(oetreotide)生长抑素受体(SSTR)显像与脑膜瘤病理分级之间的关系.方法对30例脑膜瘤患者静脉注射740-925 MBq99Tcm-HYNIC-octreotide,4h后行SPECT/CT头部断层显像,研究脑膜瘤和对侧相应部位放射性计数比(T/NT)值与病理级别的关系.对所有患者均行病理免疫组织荧光检测,观察SSTR2亚型(SSTR2)的表达情况及其与T/NT值的关系.采用SPSS11.0软件,组间T/NT值比较行t检验.T/NT值与病理级别、免疫荧光级别关系行Spearman相关分析.结果 30例脑膜瘤均呈放射性中、高度浓聚,显像阳性率为100%.20例I级脑膜瘤T/NT值为4.15±1.59,90%的可信区间为(1.53,6.77);10例Ⅱ级脑膜瘤T/NT值为9.78±1.72,90%的可信区间为(6.95,12.61),两者的差异有统计学意义(t=3.396,P=0.002).所有脑膜瘤均表达SSTR2.T/NT值与脑膜瘤病理级别、免疫荧光级别均呈正相关(r=O.824,0.851,P均<0.01).结论 99Tcm-HYNIC-octreotide显像对于脑膜瘤的病理分级诊断有一定的临床价值.
목적 탐토뇌막류99Tcm-련정니극선알(HYNIC)일오곡태(oetreotide)생장억소수체(SSTR)현상여뇌막류병리분급지간적관계.방법 대30례뇌막류환자정맥주사740-925 MBq99Tcm-HYNIC-octreotide,4h후행SPECT/CT두부단층현상,연구뇌막류화대측상응부위방사성계수비(T/NT)치여병리급별적관계.대소유환자균행병리면역조직형광검측,관찰SSTR2아형(SSTR2)적표체정황급기여T/NT치적관계.채용SPSS11.0연건,조간T/NT치비교행t검험.T/NT치여병리급별、면역형광급별관계행Spearman상관분석.결과 30례뇌막류균정방사성중、고도농취,현상양성솔위100%.20례I급뇌막류T/NT치위4.15±1.59,90%적가신구간위(1.53,6.77);10례Ⅱ급뇌막류T/NT치위9.78±1.72,90%적가신구간위(6.95,12.61),량자적차이유통계학의의(t=3.396,P=0.002).소유뇌막류균표체SSTR2.T/NT치여뇌막류병리급별、면역형광급별균정정상관(r=O.824,0.851,P균<0.01).결론 99Tcm-HYNIC-octreotide현상대우뇌막류적병리분급진단유일정적림상개치.
Objective Octreotide is a somatostatin analogy with a high affinity to somatostatin recep-tor subtype 2(SSTR2).Meningionms were shown to express SSTR2 above 80%.Convention imaging can be used to diagnose meningioma,but they can not reflect the pathological grade of meningioma. The aim of this study was to explore the relationship between 99Tcm-hydrazinonieotinamide(HYNIC)-octreotide imaging and the pathological grade of meningioma.Methods Thirty meningiomas were performed head transverse ima-ging of SSTR scintillography(SRS)with SPECT/CT after 4 h intravenous injection of 740-925 MBq 99Tcm-HYNIC-octreotide.Furthermore,the relationships between tumor and corresponding region of opposite side (T/NT)and its grade of pathology were investigated.All the pathological tissues were checked with immu-nofluorescence.The l-test was used to compare T/NT ratios.Spearman analysis was used to analyze the re-lation of T/NT ratios and pathological grade or immunofluorescence.Results Totally 30 meningioma pa-tients were included.The rate of positive imaging and expression of SSTR2 were 100%in all.The value in grade I of meningioma was 4.15±1.59[90%confidence interval(CI)=1.53 to 6.77]and was 9.78±1.72(90% CI:6.95 to 12.61)in grade II(t=3.396,P=0.002).Positive correlation relationship be-tween T/NT and the level of immunofluorescence was observed in both grade I and II meningioma(r=0.824,0.85 1;P<0.01).Conclusion 99Tcm-HYNIC-octreotide SPECT/CT imaging has potential to pre-dict the pathology grade of meningioma.