国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2010年
1期
18-20
,共3页
转化生长因子α%肝炎,慢性%肝再生
轉化生長因子α%肝炎,慢性%肝再生
전화생장인자α%간염,만성%간재생
Transforming growth factor alpha%Hepatitis,chronic%Liver regeneration
目的 研究慢性病毒性肝炎患者血清TGF-a水平变化及其与肝功能生化指标、预后等的关系,探讨TGF-a作为反映慢性肝炎患者肝细胞损害严重程度或再生情况指标的可行性. 方法 采用ELISA 方法对26例慢性重型肝炎患者、30例慢性乙型肝炎患者及20例正常人的血清TGF-a水平进行检测,并结合临床资料进行分析. 结果 (1)慢性乙型肝炎组血清TGF-a水平较对照组升高(P＜0.01).(2)不同预后的慢性重型肝炎患者血清TGF-a水平存在差异,有效组(包括临床治愈出院、好转出院)血清TGF-a含量较正常对照组显著升高(P＜0.05),无效组(包括过渡到肝移植、自动出院、死亡)略降低但差异无统计学意义(P＞0.05).(3)在慢性乙型肝炎组中,血清TGF-a含量与ALT、AST、总胆红素(TBil)及白蛋白(ALB)均无相关性;在慢性重型肝炎组中,血清TGF-α含量与ALT、AST、TBil、ALB及凝血酶原时间(PT)均无相关性.血清TGF-a含量与甲胎蛋白(AFP)呈正相关(rs=0.763,P＜0.01). 结论 (1)不同预后的慢性重型肝炎患者血清TGF-a水平存在差异;(2)血清TGF-a水平在一定程度上能反映肝细胞的再生情况.
目的 研究慢性病毒性肝炎患者血清TGF-a水平變化及其與肝功能生化指標、預後等的關繫,探討TGF-a作為反映慢性肝炎患者肝細胞損害嚴重程度或再生情況指標的可行性. 方法 採用ELISA 方法對26例慢性重型肝炎患者、30例慢性乙型肝炎患者及20例正常人的血清TGF-a水平進行檢測,併結閤臨床資料進行分析. 結果 (1)慢性乙型肝炎組血清TGF-a水平較對照組升高(P＜0.01).(2)不同預後的慢性重型肝炎患者血清TGF-a水平存在差異,有效組(包括臨床治愈齣院、好轉齣院)血清TGF-a含量較正常對照組顯著升高(P＜0.05),無效組(包括過渡到肝移植、自動齣院、死亡)略降低但差異無統計學意義(P＞0.05).(3)在慢性乙型肝炎組中,血清TGF-a含量與ALT、AST、總膽紅素(TBil)及白蛋白(ALB)均無相關性;在慢性重型肝炎組中,血清TGF-α含量與ALT、AST、TBil、ALB及凝血酶原時間(PT)均無相關性.血清TGF-a含量與甲胎蛋白(AFP)呈正相關(rs=0.763,P＜0.01). 結論 (1)不同預後的慢性重型肝炎患者血清TGF-a水平存在差異;(2)血清TGF-a水平在一定程度上能反映肝細胞的再生情況.
목적 연구만성병독성간염환자혈청TGF-a수평변화급기여간공능생화지표、예후등적관계,탐토TGF-a작위반영만성간염환자간세포손해엄중정도혹재생정황지표적가행성. 방법 채용ELISA 방법대26례만성중형간염환자、30례만성을형간염환자급20례정상인적혈청TGF-a수평진행검측,병결합림상자료진행분석. 결과 (1)만성을형간염조혈청TGF-a수평교대조조승고(P＜0.01).(2)불동예후적만성중형간염환자혈청TGF-a수평존재차이,유효조(포괄림상치유출원、호전출원)혈청TGF-a함량교정상대조조현저승고(P＜0.05),무효조(포괄과도도간이식、자동출원、사망)략강저단차이무통계학의의(P＞0.05).(3)재만성을형간염조중,혈청TGF-a함량여ALT、AST、총담홍소(TBil)급백단백(ALB)균무상관성;재만성중형간염조중,혈청TGF-α함량여ALT、AST、TBil、ALB급응혈매원시간(PT)균무상관성.혈청TGF-a함량여갑태단백(AFP)정정상관(rs=0.763,P＜0.01). 결론 (1)불동예후적만성중형간염환자혈청TGF-a수평존재차이;(2)혈청TGF-a수평재일정정도상능반영간세포적재생정황.
Objective To investigate the serum level of TGF-α in chronic hepatitis patients and the relation between TGF-α and hepatic function index, regeneration as well as prognosis. Methods The serum level of TGF-α in 26with chronic severe hepatitis patients, 30 chronic hepatitis B patients and 20 healthy individual (control group)was detected by ELISA. Results (1)Serum TGF-α level in chronic hepatitis B patients was much higher than in control group( P＜0.01). (2)There were differences in serum level of TGF-α among the chronic severe hepatitis patients with different prognosis: TGF-αlevel in good prognosis patients was much higher than in healthy individual(P＜0.05), TGF-α level in poor prognosis was slightly decreased, but there was no statistical significance(P＞0.05)between the patients and healthy individuals. (3)In group with chronic hepatitis B,the serum TGF-α level had no relation with the serum level of ALT, AST, ALB and Tbil, and in group with chronic severe hepatitis, the serum level of TGF-α also had no relation with theserum level of ALT, PI, Tbil, ALB and prothrombin time(PT). But the serum level of TGF-α was positive correlation with AFP(rs=0.763, P＜0.01). Conclusions (1) There are differences among the serum TGF-α level in chronic severe hepatitis patients with different prognosis. (2)In a sense, the serum TGF-α level can reflect the state of hepatocyte regeneration.
