CAJ | 학술논문

目的探讨不同性别的甲状腺功能亢进症(甲亢)患者血清尿酸水平变化特点.方法选择在我院住院及部分门诊就诊的120例初诊甲亢患者为观察组,其中男性42例、绝经后女性33例、绝经前女性45例.另选择120例在我院进行体检的健康者为对照组,男性、绝经后女性、绝经前女性各40例.两组受检者均隔夜空腹8 h以上测定血清尿酸水平.结果观察组男性、绝经后女性、绝经前女性血清尿酸水平分别为(396±113)μmol/L、(309 4-128)μmol/L、(316±103)μmol/L,对照组分别为(318±100)μmol/L、(310±105)μmol/L、(267±88)μmol/L,两组男性、绝经前女性血清尿酸水平间差异有统计学意义(P<0.05).结论男性及绝经前女性甲亢患者血清尿酸水平显著高于健康者,提示甲亢作为一种消耗性疾病,其高代谢状态可导致尿酸代谢异常,使血尿酸水平升高.
목적 탐토불동성별적갑상선공능항진증(갑항)환자혈청뇨산수평변화특점.방법 선택재아원주원급부분문진취진적120례초진갑항환자위관찰조,기중남성42례、절경후녀성33례、절경전녀성45례.령선택120례재아원진행체검적건강자위대조조,남성、절경후녀성、절경전녀성각40례.량조수검자균격야공복8 h이상측정혈청뇨산수평.결과 관찰조남성、절경후녀성、절경전녀성혈청뇨산수평분별위(396±113)μmol/L、(309 4-128)μmol/L、(316±103)μmol/L,대조조분별위(318±100)μmol/L、(310±105)μmol/L、(267±88)μmol/L,량조남성、절경전녀성혈청뇨산수평간차이유통계학의의(P<0.05).결론 남성급절경전녀성갑항환자혈청뇨산수평현저고우건강자,제시갑항작위일충소모성질병,기고대사상태가도치뇨산대사이상,사혈뇨산수평승고.
Objective To explore the changes of serum uric acid (SUA) level in male or female patients with hyper-thyroidism ( HT). Methods One hundred twenty patients preliminarily diagnosed as HT in our hospital were enrolled to observation group (42 males, 33 postmenopausal females, 43 premenopausal) , and another 120 healthy subjects to control (40 males, 40 postmenopausal females, 40 premenopausal). SUA levels were determined after more than 8 h fasting overnight in 2 groups. Results SUA of males, postmenopausal females and premenopausal were (396 ± 113) μmol/L, (309 ±128) μnol/ L, (316 ± 103) μmol/L, respectively, in observation group, and(318±100) μnol/L, (310±105) μnol/L, (267 ± 88) μmol/L, respectively, in control. There was significant difference in SUA between males and premenopausal females in 2 groups ( P < 0.05). Conclusion SUA levels of male and premenopausal female HT patients are significantly higher than those of healthy subjects, suggesting that HT is wasting disease, and its high metabolic state may lead to abnormal uric acid metabolism to raise SUA levels.