CAJ | 학술논문

目的探讨乙型肝炎肝硬化患者糖代谢异常与乙型肝炎病毒免疫指标的相关性.方法对128例乙型肝炎肝硬化患者行75 g口服葡萄糖耐量(OGTT)试验和乙型肝炎免疫学指标检测,以糖代谢异常情况分为糖耐量正常(NGT)组、糖调节受损(IGR)组、糖尿病(DM)组.结果三组患者腰围、体质量指数等差异均有统计学意义(F=22.71、24.62,均P＜0.05)；随着糖代谢异常加重,NGT组、IGR组以及DM组的HBsAg、HBeAg和前S1抗原阳性率均逐渐升高,三组间差异均有统计学意义(F=17.35、21.47、19.37,均P＜0.05).结论乙型肝炎肝硬化患者糖代谢异常与病毒感染有关,患者腰围、体质量指数等均与患者糖代谢异常有密切关系.
목적 탐토을형간염간경화환자당대사이상여을형간염병독면역지표적상관성.방법 대128례을형간염간경화환자행75 g구복포도당내량(OGTT)시험화을형간염면역학지표검측,이당대사이상정황분위당내량정상(NGT)조、당조절수손(IGR)조、당뇨병(DM)조.결과 삼조환자요위、체질량지수등차이균유통계학의의(F=22.71、24.62,균P＜0.05)；수착당대사이상가중,NGT조、IGR조이급DM조적HBsAg、HBeAg화전S1항원양성솔균축점승고,삼조간차이균유통계학의의(F=17.35、21.47、19.37,균P＜0.05).결론 을형간염간경화환자당대사이상여병독감염유관,환자요위、체질량지수등균여환자당대사이상유밀절관계.
Objective To investigate the correlation between hepatitis B induced cirrhosis glucose metaboliam disorders and hepatitis B immune related indexes,to analyze the epidemic characteristics in the local region.Methods 128 cases with hepatitis B induced cirrhosis were divided into the NGT group,IGR group and DM group,according to 75g oral glucose tolerance test(OGTT).Results The difference of waist size,and body mass index data in the three groups had statistically significant difference( F =22.71,24.62,all P ＜ 0.05 ).As the aggravating of glu cose metabolism disorder,the positive rate of HBsAg,HBeAg and former S1 antigen of NGT group,IGR group and DM group were gradually raised,and the differences were statistically significant ( F =17.35,21.47,19.37,all P ＜0.05).Conclusion There was positive correlation between virus infection in patients with hepatitis B induced cirrhosis and glucose metabolism disorder.There were intimate connection between the epidemiological factors such as age,waist size,weight,and body mass index and glucose metabolism disorder in patients with hepatitis B induced cirrhosis.