CAJ | 학술논문

目的探讨急性白血病(AL)免疫表型与预后的关系.方法采用流式细胞技术(FCM)对75例AL患者进行免疫表型分析,并评价不同的免疫表型对预后的影响.结果 (1)82%的急性髓性白血病(AML)患者表达CD13、CD33、CD64、CD117,88%的急性淋巴细胞性白血病(ALL)患者表达CD2、CD3、CD7、CD19、CD20,伴淋系抗原表达的AML(Ly+AML)占13%,伴髓系抗原表达的ALL(My+ALL)占11%.(2)按免疫表型的表达特征,在AML和ALL中以系列专一表达所占的比例最高,且临床治疗预后较好.裸细胞型表达在AML和ALL中所占的比例最少,且临床治疗预后极差.杂合表达的病例中,CD7+的AML患者的完全缓解率(CR)明显低于系列专一表达者,预后极差.结论 AL免疫表型可出现系列专一表达、杂合表达及裸细胞型表达三种类型.杂合表达和裸细胞型表达的患者CR率低于系列专一表达者,临床预后不好.
목적 탐토급성백혈병(AL)면역표형여예후적관계.방법 채용류식세포기술(FCM)대75례AL환자진행면역표형분석,병평개불동적면역표형대예후적영향.결과 (1)82%적급성수성백혈병(AML)환자표체CD13、CD33、CD64、CD117,88%적급성림파세포성백혈병(ALL)환자표체CD2、CD3、CD7、CD19、CD20,반림계항원표체적AML(Ly+AML)점13%,반수계항원표체적ALL(My+ALL)점11%.(2)안면역표형적표체특정,재AML화ALL중이계렬전일표체소점적비례최고,차림상치료예후교호.라세포형표체재AML화ALL중소점적비례최소,차림상치료예후겁차.잡합표체적병례중,CD7+적AML환자적완전완해솔(CR)명현저우계렬전일표체자,예후겁차.결론 AL면역표형가출현계렬전일표체、잡합표체급라세포형표체삼충류형.잡합표체화라세포형표체적환자CR솔저우계렬전일표체자,림상예후불호.
Objective To study the relationship of immunophenotype and prognosis of acute leukemia(AL). Methods 75 patients with AL were analyzed immunophenotype expression by FCM and evaluated the effect of differ-ent immunophenotype to prognosis. Results (1) The incidence of CD13, CD33, CD64, CD117 expression in AML was 82%. The incidence of CD2, CD3, CD7, CD19, CD20 expression in ALL was 88%. The incidence of lymphocytic lineage antigen expression in AML(Ly + AML) was 13% and myeloid lineage antigen expression in ALL(My + ALL) was 11%. (2)According to the antigen expression, AL could be classified into three subgroups:lineage-specific expres-sion;mixture-lineage expression and null type. The lineage-specific expression was the highest in AML and ALL, and had a better clinical prognosis. The null type was the lowest neither in AML nor ALL and had a poorer clinical progno-sis. In mixture-lineage expression the CR rate of AML with CD7+ was the lowest than those with lineage-specific ex-pression and had poorer prognosis. Conclusions AL immtmophenotype might be devided into three subgroups:line-age-specific expression; mixture-lineage expression and null type. In the patients with CD7+ AML and null type ex-pression,lower CR rate and poorer prognosis were seen than those with lineage-specific expression. It needed to ex-plore new treatment methods.