中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2011年
10期
1030-1036
,共7页
李晓蕾%于锋%张永%仇锦春%刘思婷%廖清船
李曉蕾%于鋒%張永%仇錦春%劉思婷%廖清船
리효뢰%우봉%장영%구금춘%류사정%료청선
急性淋巴细胞白血病%5,10-亚甲基四氢叶酸还原酶%基因多态性%Meta分析
急性淋巴細胞白血病%5,10-亞甲基四氫葉痠還原酶%基因多態性%Meta分析
급성림파세포백혈병%5,10-아갑기사경협산환원매%기인다태성%Meta분석
Acute lymphoblastic leukemia%5,10-methylenetrahydrofolate reductase%Gene polymorphism%Meta-analysis
目的 运用Meta分析的方法综合评价5,10-亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与急性淋巴细胞白血病(ALL)的相关性.方法 制定原始文献的纳入和排除标准及检索策略.检索中外文数据库,收集有关MTHFR基因C677T多态性与ALL相关性的研究报告,采用TT/CC+CT以及TT/CC基因型比较模型进行定量综合分析,然后按年龄(儿童或成年人)分亚组进行分析.结果 综合分析显示,MTHFR基因677位点TT/CC+ CT、TT/CC模型计算OR值(95％CI)分别为0.87(0.69～1.09)、0.82(0.63～ 1.06);在儿童组TT/CC+ CT、TT/CC模型计算OR值(95％CI)分别为0.92(0.79～1.08)、0.88(0.75～1.05),在成年人组TT/CC+CT、TT/CC模型计算OR值(95％CI)分别为0.45(0.26 ～0.77)、0.41(0.22～0.72).结论 MTHFR基因C677T突变与儿童ALL无关联,但可能减弱成年人ALL发生的危险.
目的 運用Meta分析的方法綜閤評價5,10-亞甲基四氫葉痠還原酶(MTHFR)基因C677T多態性與急性淋巴細胞白血病(ALL)的相關性.方法 製定原始文獻的納入和排除標準及檢索策略.檢索中外文數據庫,收集有關MTHFR基因C677T多態性與ALL相關性的研究報告,採用TT/CC+CT以及TT/CC基因型比較模型進行定量綜閤分析,然後按年齡(兒童或成年人)分亞組進行分析.結果 綜閤分析顯示,MTHFR基因677位點TT/CC+ CT、TT/CC模型計算OR值(95％CI)分彆為0.87(0.69～1.09)、0.82(0.63～ 1.06);在兒童組TT/CC+ CT、TT/CC模型計算OR值(95％CI)分彆為0.92(0.79～1.08)、0.88(0.75～1.05),在成年人組TT/CC+CT、TT/CC模型計算OR值(95％CI)分彆為0.45(0.26 ～0.77)、0.41(0.22～0.72).結論 MTHFR基因C677T突變與兒童ALL無關聯,但可能減弱成年人ALL髮生的危險.
목적 운용Meta분석적방법종합평개5,10-아갑기사경협산환원매(MTHFR)기인C677T다태성여급성림파세포백혈병(ALL)적상관성.방법 제정원시문헌적납입화배제표준급검색책략.검색중외문수거고,수집유관MTHFR기인C677T다태성여ALL상관성적연구보고,채용TT/CC+CT이급TT/CC기인형비교모형진행정량종합분석,연후안년령(인동혹성년인)분아조진행분석.결과 종합분석현시,MTHFR기인677위점TT/CC+ CT、TT/CC모형계산OR치(95％CI)분별위0.87(0.69～1.09)、0.82(0.63～ 1.06);재인동조TT/CC+ CT、TT/CC모형계산OR치(95％CI)분별위0.92(0.79～1.08)、0.88(0.75～1.05),재성년인조TT/CC+CT、TT/CC모형계산OR치(95％CI)분별위0.45(0.26 ～0.77)、0.41(0.22～0.72).결론 MTHFR기인C677T돌변여인동ALL무관련,단가능감약성년인ALL발생적위험.
Objective To evaluate the association between polymorphism of 5,10-methylenetrahydrofolate reductase C677T and risk of acute lymphoblastic leukemia (ALL).Methods Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers,according to the inclusion and exclusion criteria.Data on case-control studies on association between MTHFR C677T polymorphism and susceptibility to ALL were colleted and analyzed by models of TT vs.CC + CT or TT vs.CC through Meta-analysis.Stratified analysis was carried out according to different age groups (children or adult).Results In systematical analysis,the pooled odds ratios of MTHFR C677T genetype TT vs.CC + CT or TT vs.CC were 0.87(0.69-1.09 ) and 0.82 ( 0.63-1.06 ) respectively; in children' s group,the pooled odds ratios of MTHFR C677T genetype TT vs.CC + CT or TT vs.CC were 0.92 ( 0.79-1.08),0.88 ( 0.75-1.05 ) while in adult group,the pooled odds ratios of MTHFR C677T genetype TT vs.CC + CT or TT vs.CC were 0.45(0.26-0.77),and 0.41 (0.22-0.72) respectively.Conclusion The MTHFR gene 677T variant might not be associated with the risk of children's ALL but might be associated with a reduced risk on adult's ALL.
