中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2010年
11期
900-903
,共4页
叶再元%吕振晔%邵钦树%张威%孙元水%张勤%李曙光%王元宇%徐继
葉再元%呂振曄%邵欽樹%張威%孫元水%張勤%李曙光%王元宇%徐繼
협재원%려진엽%소흠수%장위%손원수%장근%리서광%왕원우%서계
胃肠吻合术%胃泌素类%胆囊收缩素%疾病模型,动物
胃腸吻閤術%胃泌素類%膽囊收縮素%疾病模型,動物
위장문합술%위비소류%담낭수축소%질병모형,동물
Gastroenterostomy%Gastrins%Cholecystokinin%Disease modals,animal
目的 通过建立成年Beagle犬远端胃大部切除模型,探讨远端胃大部切除连续空肠间置对Beagle犬胃肠激素的影响.方法 将24只成年Beagle犬随机分为连续性空肠间置组(连续间置组)、Billroth Ⅱ吻合组(毕Ⅱ组)、空肠孤立间置组(孤立间置组).应用酶联免疫法测定在远端胃大部切除术后分别行毕Ⅱ式、空肠孤立间置、连续间置术后犬血浆胃泌素、胃动素和胆囊收缩素的水平.结果 连续间置组术后2个月血浆胃泌素水平餐前为(2.2±0.7)ng/L、餐后为(3.9±0.8)ng/L,均低于术前的(3.8±1.0)ng/L、(5.3±1.6)ng/L,P<0.05.连续空肠间置组术后2个月餐后血浆胃泌素水平为(3.9±0.8)ng/L,高于其他2组的(2.7±1.0)ng/L和(3.6±0.6)ng/L,P<0.05;连续间置组术后2个月血浆胃动素水平餐前为(577±204)ng/L、餐后为(1003±209)ng/L,均高于术前的(429±128)ng/L、(854±218)ng/L,P<0.05.连续间置组术后2个月餐后血浆胃动素水平为(1003±209)ng/L,高于其他2组的(840±205)ng/L、(986±189)ng/L,P<0.05;连续间置组术后2个月血浆胆囊收缩素水平为(19.6±2.0)ng/L,高于术前的(19.0±2.0)ng/L,P<0.05,低于其他2组的(22.2±2.1)ng/L、(20.1±2.5)ng/L.结论 远端胃大部切除术后行连续性空肠间置能使犬血浆胃动素和胃泌素在术后维持一个相对较高的水平,而血浆胆囊收缩素则维持一个相对较低的水平.
目的 通過建立成年Beagle犬遠耑胃大部切除模型,探討遠耑胃大部切除連續空腸間置對Beagle犬胃腸激素的影響.方法 將24隻成年Beagle犬隨機分為連續性空腸間置組(連續間置組)、Billroth Ⅱ吻閤組(畢Ⅱ組)、空腸孤立間置組(孤立間置組).應用酶聯免疫法測定在遠耑胃大部切除術後分彆行畢Ⅱ式、空腸孤立間置、連續間置術後犬血漿胃泌素、胃動素和膽囊收縮素的水平.結果 連續間置組術後2箇月血漿胃泌素水平餐前為(2.2±0.7)ng/L、餐後為(3.9±0.8)ng/L,均低于術前的(3.8±1.0)ng/L、(5.3±1.6)ng/L,P<0.05.連續空腸間置組術後2箇月餐後血漿胃泌素水平為(3.9±0.8)ng/L,高于其他2組的(2.7±1.0)ng/L和(3.6±0.6)ng/L,P<0.05;連續間置組術後2箇月血漿胃動素水平餐前為(577±204)ng/L、餐後為(1003±209)ng/L,均高于術前的(429±128)ng/L、(854±218)ng/L,P<0.05.連續間置組術後2箇月餐後血漿胃動素水平為(1003±209)ng/L,高于其他2組的(840±205)ng/L、(986±189)ng/L,P<0.05;連續間置組術後2箇月血漿膽囊收縮素水平為(19.6±2.0)ng/L,高于術前的(19.0±2.0)ng/L,P<0.05,低于其他2組的(22.2±2.1)ng/L、(20.1±2.5)ng/L.結論 遠耑胃大部切除術後行連續性空腸間置能使犬血漿胃動素和胃泌素在術後維持一箇相對較高的水平,而血漿膽囊收縮素則維持一箇相對較低的水平.
목적 통과건립성년Beagle견원단위대부절제모형,탐토원단위대부절제련속공장간치대Beagle견위장격소적영향.방법 장24지성년Beagle견수궤분위련속성공장간치조(련속간치조)、Billroth Ⅱ문합조(필Ⅱ조)、공장고립간치조(고립간치조).응용매련면역법측정재원단위대부절제술후분별행필Ⅱ식、공장고립간치、련속간치술후견혈장위비소、위동소화담낭수축소적수평.결과 련속간치조술후2개월혈장위비소수평찬전위(2.2±0.7)ng/L、찬후위(3.9±0.8)ng/L,균저우술전적(3.8±1.0)ng/L、(5.3±1.6)ng/L,P<0.05.련속공장간치조술후2개월찬후혈장위비소수평위(3.9±0.8)ng/L,고우기타2조적(2.7±1.0)ng/L화(3.6±0.6)ng/L,P<0.05;련속간치조술후2개월혈장위동소수평찬전위(577±204)ng/L、찬후위(1003±209)ng/L,균고우술전적(429±128)ng/L、(854±218)ng/L,P<0.05.련속간치조술후2개월찬후혈장위동소수평위(1003±209)ng/L,고우기타2조적(840±205)ng/L、(986±189)ng/L,P<0.05;련속간치조술후2개월혈장담낭수축소수평위(19.6±2.0)ng/L,고우술전적(19.0±2.0)ng/L,P<0.05,저우기타2조적(22.2±2.1)ng/L、(20.1±2.5)ng/L.결론 원단위대부절제술후행련속성공장간치능사견혈장위동소화위비소재술후유지일개상대교고적수평,이혈장담낭수축소칙유지일개상대교저적수평.
Objective To evaluate effects of alimentary reconstruction procedures (integral continual jejunal interposition, Billroth Ⅱ and isolated jejunal interposition) after subtotal gastrectomy on postoperative plasma gastrin, motilin and cholecystokinin. Methods Twenty-four dogs were divided into 3 groups undergoing distal subtotal gastrectomy and three different digestive tract reconstruction (integral continual jejunal interposition, Billroth Ⅱ and isolated jejunal interposition). The concentration of plasma gastrin, motilin and cholecystokinin were detected by enzyme-linked immunosorbent assay before and after operation. Results Two months after operation, plasma gastrin level of the integral continual jejunal interposition group (2. 2 ±0. 7 ) ng/L, ( 3.9 ± 0. 8 ) ng/L was significantly lower than that of preoperative both in fasting and postprandial state (3.8 ± 1.0) ng/L, (5.3 ± 1.6) ng/L, all P <0.05, but was significantly higher than other two groups in postprandial state (2. 7 ± 1.0) ng/L, (3.6 ±0. 6) ng/L, P <0. 05. Two months after operation, plasma motilin concentration of integral continual jejunal interposition group (577 ±204) ng/L, (1003 ± 209) ng/L were significantly higher than that of preoperative both in fasting and postprandial (429 ± 128) ng/L, (854 ± 218 ) ng/L, P < 0. 05. The postoperative plasma motilin of integral continual jejunal interposition group ( 1003 ± 209 ) ng/L was significantly higher than other two groups in postprandial state (840 ±205) ng/L, (986 ± 189) ng/L, P <0. 05. Two months after operation,plasma cholecystokinin concentration of integral continual jejunal interposition group ( 19.6 ± 2.0 ) ng/Lwere significantly higher than that of preoperative both in postprandial ( 19.0 ± 2. 0) ng/L, P < 0. 05. The postoperative plasma cholecystokinin of integral continual jejunal interposition group ( 19. 6 ± 2. 0) ng/L was significantly lower than other two groups (22.2 ± 2. 1 ) ng/L, (20. 1 ± 2. 5 ) ng/L, P < 0. 05. Conclusion Integral continual jejunal interposition after distal gastrectomy maintains the postoperative plasma motilin and gastrin in a relatively higher level and decreases the concentration of plasma cholecystokinin.