中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2009年
3期
161-164
,共4页
重症肌无力%受体,胆碱能%受体,促甲状腺素%甲状腺球蛋白%自身抗体
重癥肌無力%受體,膽堿能%受體,促甲狀腺素%甲狀腺毬蛋白%自身抗體
중증기무력%수체,담감능%수체,촉갑상선소%갑상선구단백%자신항체
Myasthenia gravis%Receptors,cholinergic%Receptors,thyrotropin%Thyro-globulin: Autoantibodies
目的 研究重症肌无力(MG)与甲状腺异常在抗体方面的相关性.方法 比较100例MG患者和100名健康对照在甲状腺功能、甲状腺抗体异常率方面的差异.随机选取其中32例MG患者,探讨其血清乙酰胆碱受体(AChR)抗体与促甲状腺激素受体抗体(TRAb)、甲状腺球蛋白抗体(TGAb)和甲状腺微粒体抗体(TMAb)的相关性及临床特点.结果 100例MG中,甲状腺功能亢进(甲亢)和甲状腺功能减退(甲减)者共16例(16%),甲状腺抗体检查阳性者71例(71%),甲状腺抗体阳性率高于甲状腺功能阳性率(χ2=4.788,P<0.05).32例MG血清AChR抗体与TRAb浓度存在线性相关(r=0.609,P=0.O002).结论 MG患者出现甲状腺抗体异常比出现甲亢或甲减更多见.MG血清AChR抗体与TRAb浓度存在线性相关.
目的 研究重癥肌無力(MG)與甲狀腺異常在抗體方麵的相關性.方法 比較100例MG患者和100名健康對照在甲狀腺功能、甲狀腺抗體異常率方麵的差異.隨機選取其中32例MG患者,探討其血清乙酰膽堿受體(AChR)抗體與促甲狀腺激素受體抗體(TRAb)、甲狀腺毬蛋白抗體(TGAb)和甲狀腺微粒體抗體(TMAb)的相關性及臨床特點.結果 100例MG中,甲狀腺功能亢進(甲亢)和甲狀腺功能減退(甲減)者共16例(16%),甲狀腺抗體檢查暘性者71例(71%),甲狀腺抗體暘性率高于甲狀腺功能暘性率(χ2=4.788,P<0.05).32例MG血清AChR抗體與TRAb濃度存在線性相關(r=0.609,P=0.O002).結論 MG患者齣現甲狀腺抗體異常比齣現甲亢或甲減更多見.MG血清AChR抗體與TRAb濃度存在線性相關.
목적 연구중증기무력(MG)여갑상선이상재항체방면적상관성.방법 비교100례MG환자화100명건강대조재갑상선공능、갑상선항체이상솔방면적차이.수궤선취기중32례MG환자,탐토기혈청을선담감수체(AChR)항체여촉갑상선격소수체항체(TRAb)、갑상선구단백항체(TGAb)화갑상선미립체항체(TMAb)적상관성급림상특점.결과 100례MG중,갑상선공능항진(갑항)화갑상선공능감퇴(갑감)자공16례(16%),갑상선항체검사양성자71례(71%),갑상선항체양성솔고우갑상선공능양성솔(χ2=4.788,P<0.05).32례MG혈청AChR항체여TRAb농도존재선성상관(r=0.609,P=0.O002).결론 MG환자출현갑상선항체이상비출현갑항혹갑감경다견.MG혈청AChR항체여TRAb농도존재선성상관.
Objective To study the relationship of levels of acetylcholine receptor antibody (AChRAb) and thyroid antibodies in patients with myasthenia gravis (MG) and thyroidism. Methods Thyroid function of FT3, FT4 and TSH, and thyroid antibodies including TSH receptor antibody ( TRAb), thyroid globulin antibody (TGAb) and thyroid microsome antibody (TMAb) were detected in 100 patients with MG and 100 healthy controls. Among them, 32 patients were further tested for AChRAb. The relationship between AChRAb and each of TRAb, TGAb and TMAb was analyzed along with their relevant clinical characteristics. Results Of 100 patients with MG, 12 cases ( 12% ) were hyperthyroidism and 4 cases (4%) were hypothyroidism, and 71 cases (71%) were thyroid antibodies positive. The percent of thyroid antibodies positive cases was significantly higher than that of thyroidism cases (χ2=4. 788, P < 0. 05 ). Analysis on AChRAb and TRAb in 32 AChRAb tested cases demonstrated a linear correlation (r= 0. 609, P = 0. 0002). Conclusions The incidence of thyroid antibody positive in MG cases is significantly higher than incidence of hyperthyroidism and hypothyroidism in MG. AChRAb and TRAb has a linear correlation.
