CAJ | 학술논문

目的评估氩离子凝固术(APC)联合质子泵抑制剂(PPI)逆转Barrett食管(BE)的长期疗效.方法对2004年至2007年经胃镜检查并经病理证实的36例BE患者采用APC联合PPI(每天20mg)治疗,分别于治疗后第1、6、12个月复查,以后每年1次内镜随访.结果 36例患者共行48次APC治疗,平均1.33次/例,经治疗后均获得BE完全逆转.随访14～51个月,中位时间36个月,BE总复发率为16.7%(6/36),1年复发率为2.8%(1/36),2年复发率为11.1%(4/36).Logistic回归分析显示,2年复发率和总复发率与APC治疗次数呈明显正相关(P值分别为0.004和0.007).结论 APC联合PPI治疗BE是一种安全、有效的方法,且长期疗效较好.
목적 평고아리자응고술(APC)연합질자빙억제제(PPI)역전Barrett식관(BE)적장기료효.방법 대2004년지2007년경위경검사병경병리증실적36례BE환자채용APC연합PPI(매천20mg)치료,분별우치료후제1、6、12개월복사,이후매년1차내경수방.결과 36례환자공행48차APC치료,평균1.33차/례,경치료후균획득BE완전역전.수방14～51개월,중위시간36개월,BE총복발솔위16.7%(6/36),1년복발솔위2.8%(1/36),2년복발솔위11.1%(4/36).Logistic회귀분석현시,2년복발솔화총복발솔여APC치료차수정명현정상관(P치분별위0.004화0.007).결론 APC연합PPI치료BE시일충안전、유효적방법,차장기료효교호.
Objective To study the long-term effect of argon plasma coagulation (APC) combined with proton pump inhibitor (PPI) on Barrett esophagus (BE). Methods A total of 36 patients, histologically proven as having BE from 2004 to 2007, were enrolled to underwent a therapy of APC plus PPI. The patients were re-examined on endoscopy at 1, 6 and 12 months after first APC and once a year thereafter.Results A total of 48 APC sessions were given to 36 patients with a mean number at 1. 33 per patient. The effective rate of reversal of BE was 100%. The follow-up was accomplished for all patients in 14-51 months with a median of 36months. The total recurrence rate (RR) of BE reached 16. 7% (6/36). The 1-year and 2-year RRs were 2. 8% (1/36) and 11.1% (4/36), respectively. The logistic regression analysis suggested that 2-year and total RRs were related to APC sessions ( P ＜ 0. 01 ). Conclusion The therapy of APC combined with PPI for BE is safe and of long-term effects.