清华大学学报（英文版）
清華大學學報（英文版）
청화대학학보（영문판）
TSINGHUA SCIENCE AND TECHNOLOGY
2004年
4期
397-405
,共9页
谢伟东%刑东明%苏慧%程杰%金文%丁怡%杜力军
謝偉東%刑東明%囌慧%程傑%金文%丁怡%杜力軍
사위동%형동명%소혜%정걸%금문%정이%두력군
postprandial hypertriglyceridemia%diabetic gastroparesis%domperidone%lipoprotein lipase%olive oil
Both postprandial hypertriglyceridemia and diabetic gastroparesis are common dysfunctions affecting diabetes mellitus; however,whether diabetic gastroparesis has an influence on postprandial hypertriglyceridemia still remains undetermined.Delayed postprandial hypertriglyceridemia,diabetic gastroparesis,and the possible links between them were investigated using alloxan-induced diabetic mice.After the oral administration of olive oil,delayed and exaggerated postprandial hypertriglyceridemia and diabetic gastroparesis were markedly presented in alloxan-induced diabetic mice.Domperidone shortened the time of triglycerides (TG) peak levels in diabetic mice.After intraperitoneal and intraduodenal administration of olive oil,no delay of TG peak levels occurred in diabetic mice.Simultaneously,serum post-heparin lipoprotein lipase activities significantly decreased just at the time of prolonged and elevated TG peak levels resulting from diabetic gastroparesis,and further deteriorated postprandial hypertriglyceridemia in diabetic mice.The results indicate that diabetic gastroparesis can be one of the important reasons for delayed and exaggerated postprandial hypertriglyceridemia in diabetes mellitus.
