CAJ | 학술논문

以正庚烷为溶剂，对全合成β-胡萝卜素中二氯甲烷的去除方法进行了初步研究。以二氯甲烷的溶剂残留量、β-胡萝卜素的含量及收率为主要指标，采用单因素分析法对正庚烷的使用量、搅拌时间、搅拌温度、乙醇含水量、乙醇投料量、精制温度等6个条件进行优化。实验结果表明：30倍（v／w）正庚烷溶解β-胡萝卜素，在70℃下搅拌回流2h，再经真空回收溶剂脱溶，加入无水乙醇在78℃下保温精制2h，冷却结晶并过滤真空干燥，这一方案对β-胡萝卜素中的二氯甲烷的去除具有很好的效果、并获得较高的含量和较好的收率。
이정경완위용제，대전합성β-호라복소중이록갑완적거제방법진행료초보연구。이이록갑완적용제잔류량、β-호라복소적함량급수솔위주요지표，채용단인소분석법대정경완적사용량、교반시간、교반온도、을순함수량、을순투료량、정제온도등6개조건진행우화。실험결과표명：30배（v／w）정경완용해β-호라복소，재70℃하교반회류2h，재경진공회수용제탈용，가입무수을순재78℃하보온정제2h，냉각결정병과려진공간조，저일방안대β-호라복소중적이록갑완적거제구유흔호적효과、병획득교고적함량화교호적수솔。
The optimal technology to remove dichloromethane from syuntheic β-carotene with heptane was investigated.With the solvent residues concentrate and content as well as recovery of final product as indexes. factors including amount of heptane, stirring time,temperature, water content of ethanol and volume, refining temperature were analyzed with single factor analysis method. At last, the optimal processes to remove dichloromethane from β-carotene,in which β-carotene crystal was dissolved in 30 times heptane （v/w） at the temperature of 70 ℃ for 2 h,after distillating of the solvent,water content of 20% ethanol with volume of 20 times （v/w） was added and then refined at 78℃ for 2 h followed crystallized during decreasing the temperature slowly,were obtained. Good effects in the removing harmful solvents and high purity as well as nice recovery could be gained in the processes.