CAJ | 학술논문

银屑病是一种与T淋巴细胞相关的自身免疫性疾病,新近研究发现除与Th1细胞有关外,Th17细胞及其相关的细胞因子在银屑病发病中也起重要的作用.T淋巴细胞的活化和分化需要抗原提呈细胞参与,肥大细胞活化后释放的细胞因子也参与银屑病发病.因此,银屑病是由多种免疫细胞和细胞因子共同参与的疾病.阐明银屑病发病的免疫机制可为银屑病治疗开辟新疗法提供理论依据.
은설병시일충여T림파세포상관적자신면역성질병,신근연구발현제여Th1세포유관외,Th17세포급기상관적세포인자재은설병발병중야기중요적작용.T림파세포적활화화분화수요항원제정세포삼여,비대세포활화후석방적세포인자야삼여은설병발병.인차,은설병시유다충면역세포화세포인자공동삼여적질병.천명은설병발병적면역궤제가위은설병치료개벽신요법제공이론의거.
Psoriasis is an autoimmune disease that is associated with T lymphocytes. Recent research has shown that besides Th1 cells, Th17 cells and related cytokines play a very important role in the pathogenesis of psoriasis. The differentiation and activation of T lymphocytes requires the participation of antigen-presenting cells. Cytokines released by activated mast cells also take part in the pathogenesis of psoriasis. Therefore, a great many of immunocytes and cytokines are involved in the development of psoriasis. To elucidate the immunologic mechanism in the pathogenesis of psoriasis may provide theoretic evidence for the development of new approaches to psoriasis treatment.