CAJ | 학술논문

中和抗体(Nab)可以防止I型人类免疫缺陷病毒(HIV-1)侵入靶细胞.HIV-1感染数周后即可诱导产生Nab,这些早期抗体只能特异性地中和自体病毒但不能中和异源性病毒.在一些慢性感染者体内则可以检测到可同时中和同源性和异源性病毒的广谱中和抗体(BNab).BNab的靶点通常位于包膜蛋白的保守区域.HIV-1 BNab的产生还受到病毒变异及结构遮盖等因素的限制,同时Nab的中和广度与病毒载量具有相关性.
중화항체(Nab)가이방지I형인류면역결함병독(HIV-1)침입파세포.HIV-1감염수주후즉가유도산생Nab,저사조기항체지능특이성지중화자체병독단불능중화이원성병독.재일사만성감염자체내칙가이검측도가동시중화동원성화이원성병독적엄보중화항체(BNab).BNab적파점통상위우포막단백적보수구역.HIV-1 BNab적산생환수도병독변이급결구차개등인소적한제,동시Nab적중화엄도여병독재량구유상관성.
Neutralizing antibodies can protect a host against the infection by human immunodeficiency virus type 1 (HIV-1).Neutralizing antibodies can be induced several weeks after infection.However,the antibodies induced in the early stage can neutralize only the autologous but not heterologous viruses.Nevertheless,broad neutralizing antibodies,which can neutralize both autologous and heterologous viruses,have been found in some chronic patients.Inaddition,broad neutralizing antibodies usually target the conserved regions of HIV-1 envelope glycoprotein.However,the envelope glycoprotein mutation and its structure shielding limit the induction of these antibodies.