CAJ | 학술논문

目的比较两种不同的兔VX2肝肿瘤模型的建立方法,评价超声在监测肿瘤生长的价值.方法使用VX2瘤组织悬液及瘤组织块在超声引导下分别对两组共30只新西兰兔进行接种,比较不同植瘤方式肿瘤的生长特点.常规超声监测肿瘤生长并与病理检查进行相关性分析.结果超声引导下经皮穿刺瘤组织块种植组与混悬液注射组成瘤率分别为66.7%(16/30)和26.7%(8/30).两组兔子原位成瘤共28个;肿瘤多为等回声,比较清楚,部分可见声晕;超声检查诊断符合率为85.7%(24/28).超声对肿瘤平均径线的测值与病理测值相关性高,能准确地反映肿瘤的生长状态.结论使用超声引导下经皮穿刺瘤块接种法比组织混悬液注射法模型制作成瘤率高、模型更稳定.超声能准确监测种植肿瘤的生长,可为临床利用该模型来评价诊治肝癌的新疗法的疗效提供有效监测方法.
목적 비교량충불동적토VX2간종류모형적건립방법,평개초성재감측종류생장적개치.방법 사용VX2류조직현액급류조직괴재초성인도하분별대량조공30지신서란토진행접충,비교불동식류방식종류적생장특점.상규초성감측종류생장병여병리검사진행상관성분석.결과 초성인도하경피천자류조직괴충식조여혼현액주사조성류솔분별위66.7%(16/30)화26.7%(8/30).량조토자원위성류공28개;종류다위등회성,비교청초,부분가견성훈;초성검사진단부합솔위85.7%(24/28).초성대종류평균경선적측치여병리측치상관성고,능준학지반영종류적생장상태.결론 사용초성인도하경피천자류괴접충법비조직혼현액주사법모형제작성류솔고、모형경은정.초성능준학감측충식종류적생장,가위림상이용해모형래평개진치간암적신요법적료효제공유효감측방법.
Objective To compare two methods for establishing rabbit models of VX2 liver tumor and to evaluate the efficacy of ultrasonography in monitoring tumor growth. Methods VX2 tumor suspension and tumor tissue were respectively inoculated into two groups of New Zealand rabbits (n=30 in total) under ultrasound guidance. Growth feature of tumors with different tumor-implanting approaches was compared between the two groups. Routine ultrasonic was applied to monitor tumor growth and correlation analysis was performed between the ultrasound findings and pathology. Results The tumor formation rate with ultrasound- guided tumor tissue implantation was 66.7% (16/30) vs 26.7% (8/30) with tumor suspension injection. Twenty-eight tumors in situ were detected from both groups. Under the ultrasound, most tumors were isoechoic and clear, and some were with surrounding echo halo. The ultrasonic diagnosis was 85.7% (24/28) in accordance with pathology. Ultrasonography-measured mean diameter of tumors was well correlated with that measured by pathology, indicating an accurate reflection of tumor growth. Conclusions Compared with cell suspension injection, tumor tissue implantation under ultrasound puncture is more fruitful and stable in establishment of tumor model in rabbits. Ultrasonography accurately monitors the tumor growth, and therefore can be an efficient modality in evaluating the efficacy of new therapies for liver carcinoma.