CAJ | 학술논문

目的探讨IL-1β、细胞间黏附分子(ICAM)在糖尿病肾微血管病变发生、发展中的作用.方法 62例2型糖尿病患者依据尿白蛋白排泄率(UAER)分为正常白蛋白尿组(UAER＜20μg/min)20例、微量白蛋白尿组(UAER 20～200μg/min)22例、显性白蛋白尿组(UAER＞200μg/min)20例,健康体检者20例(对照组),分别用ELISA法测定其血清中IL-1β、ICAM含量的变化.结果三组糖尿病患者IL-1β、ICAM水平均高于对照组(P＜0.05),显性白蛋白尿组IL-1β、ICAM水平高于微量白蛋白尿组、正常白蛋白尿组(P＜0.01),微量白蛋白尿组IL-1β水平高于正常白蛋白尿组(P＜0.05),微量白蛋白尿组ICAM水平与正常白蛋白尿组比较差异无统计学意义(P＞0.05).血清IL-1β、ICAM与UAER呈正相关(P＜0.05),血清IL-1β与ICAM呈正相关(P＜0.05).结论糖尿病肾微血管病变患者血清ICAM、IL-1β水平升高与UAER关系密切,可能参与其发生、发展,早期监测对糖尿病肾微血管病变的早期诊断具有临床意义.
목적 탐토IL-1β、세포간점부분자(ICAM)재당뇨병신미혈관병변발생、발전중적작용.방법 62례2형당뇨병환자의거뇨백단백배설솔(UAER)분위정상백단백뇨조(UAER＜20μg/min)20례、미량백단백뇨조(UAER 20～200μg/min)22례、현성백단백뇨조(UAER＞200μg/min)20례,건강체검자20례(대조조),분별용ELISA법측정기혈청중IL-1β、ICAM함량적변화.결과 삼조당뇨병환자IL-1β、ICAM수평균고우대조조(P＜0.05),현성백단백뇨조IL-1β、ICAM수평고우미량백단백뇨조、정상백단백뇨조(P＜0.01),미량백단백뇨조IL-1β수평고우정상백단백뇨조(P＜0.05),미량백단백뇨조ICAM수평여정상백단백뇨조비교차이무통계학의의(P＞0.05).혈청IL-1β、ICAM여UAER정정상관(P＜0.05),혈청IL-1β여ICAM정정상관(P＜0.05).결론 당뇨병신미혈관병변환자혈청ICAM、IL-1β수평승고여UAER관계밀절,가능삼여기발생、발전,조기감측대당뇨병신미혈관병변적조기진단구유림상의의.
Objective To study the influence of interleukin(IL)-1β,intercellular adhesion molecule(ICAM)on diahetic renal microangiopathy.Methods Sixty-two patients with type 2 diabetic mellitus were divided into three groups:normal albumin urine group(20 patients),microamount albumin urine group(22 patients),and dominancy albumin urine group(20 patients)according to their urinary albumin excretion rate(UAER).IL-1β,ICAM was measured by enzyme-linkedimmuno sorbent assay(ELISA)method in the type 2 diabetic mellitus and the healthy persons.Results The concentration of IL-1β,ICAM in the three groups with type 2 diabetic mellitus was higher than that of the twenty healthy persons(P＜0.05),higher in the dominancy albumin urine group than that in the microamount albumin urine and normal albumin urine groups(P＜0.01).The concentration of IL-1β in the microamount albumin urine group was higher than that in the normal albumin urine group(P＜0.05),the concentration of ICAM in the microamount albumin urine and normal albumin urine groups was equal(P＞0.05).Higher serum IL-1β and ICAM was associated with higher UAER(P＜0.05).The concentrations of IL-1βwas positively correlated with ICAM.Conclusion ICAM,IL-1β is probably correlated to UAER of diabetic renal microangiopathy,80 it has very important meaning and clinic value to measure the concentration of IL-1β,ICAM in serum earlier.