中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
11期
1178-1180
,共3页
曾国群%李奕%李贤福%钟永红
曾國群%李奕%李賢福%鐘永紅
증국군%리혁%리현복%종영홍
胃疾病%幽门螺杆菌%红细胞免疫
胃疾病%幽門螺桿菌%紅細胞免疫
위질병%유문라간균%홍세포면역
Gastric disease%Helicobacter pylori%Red blood cells immunity
目的 探讨胃疾病与红细胞免疫功能变化的研究.方法 采用花环法测定红细胞C3b受体花环率(RBCC3bRR)及免疫复合物花环率(RBCICR),对103例慢性胃炎(慢性胃炎组)和75例十二脂肠球部溃疡患者(十二指肠球部溃疡组)及30名健康者(正常对照组)进行红细胞免疫功能检测.结果 正常对照组、慢性胃炎组、十二指肠球部溃疡组RBCC3bRR分别为(20.83±5.16)％、(16.26±5.17)％、(13.65±5.19)％,RBCICR分别为(7.63±4.09)％、(10.59±4.45)％、(10.04±4.13)％.2项指标慢性胃炎组和十二指肠球部溃疡组均低于正常对照组(t分别为4.963、6.070,P均＜0.01),RBCICR分别高于正常对照组(t分别为3.262、3.456,P＜0.05或P＜0.01).HP阴性慢性胃炎与HP阴性十二指肠球部溃疡、HP阳性慢性胃炎与HP阳性十二指肠球部溃疡分别比较RBCC3hRR和RBCICR差异均无统计学意义(P均＞0.05);慢性胃炎及十二指肠球部溃疡HP阳性RBCC3bRR明显低于HP阴性者(P＜0.05或P＜0.01),RBCICR明显高于HiP阴性者(P均＜0.01),HP根除后慢性胃炎和十二指肠球部溃疡患者RBCC3bRR,分别较治疗前明显升高(P＜0.05或P＜0.01).RBCICR分别较治疗前明显降低(P均＜0.01).结论 HP感染、慢性胃炎、十二指肠溃疡均可降低红细胞免疫功能.
目的 探討胃疾病與紅細胞免疫功能變化的研究.方法 採用花環法測定紅細胞C3b受體花環率(RBCC3bRR)及免疫複閤物花環率(RBCICR),對103例慢性胃炎(慢性胃炎組)和75例十二脂腸毬部潰瘍患者(十二指腸毬部潰瘍組)及30名健康者(正常對照組)進行紅細胞免疫功能檢測.結果 正常對照組、慢性胃炎組、十二指腸毬部潰瘍組RBCC3bRR分彆為(20.83±5.16)％、(16.26±5.17)％、(13.65±5.19)％,RBCICR分彆為(7.63±4.09)％、(10.59±4.45)％、(10.04±4.13)％.2項指標慢性胃炎組和十二指腸毬部潰瘍組均低于正常對照組(t分彆為4.963、6.070,P均＜0.01),RBCICR分彆高于正常對照組(t分彆為3.262、3.456,P＜0.05或P＜0.01).HP陰性慢性胃炎與HP陰性十二指腸毬部潰瘍、HP暘性慢性胃炎與HP暘性十二指腸毬部潰瘍分彆比較RBCC3hRR和RBCICR差異均無統計學意義(P均＞0.05);慢性胃炎及十二指腸毬部潰瘍HP暘性RBCC3bRR明顯低于HP陰性者(P＜0.05或P＜0.01),RBCICR明顯高于HiP陰性者(P均＜0.01),HP根除後慢性胃炎和十二指腸毬部潰瘍患者RBCC3bRR,分彆較治療前明顯升高(P＜0.05或P＜0.01).RBCICR分彆較治療前明顯降低(P均＜0.01).結論 HP感染、慢性胃炎、十二指腸潰瘍均可降低紅細胞免疫功能.
목적 탐토위질병여홍세포면역공능변화적연구.방법 채용화배법측정홍세포C3b수체화배솔(RBCC3bRR)급면역복합물화배솔(RBCICR),대103례만성위염(만성위염조)화75례십이지장구부궤양환자(십이지장구부궤양조)급30명건강자(정상대조조)진행홍세포면역공능검측.결과 정상대조조、만성위염조、십이지장구부궤양조RBCC3bRR분별위(20.83±5.16)％、(16.26±5.17)％、(13.65±5.19)％,RBCICR분별위(7.63±4.09)％、(10.59±4.45)％、(10.04±4.13)％.2항지표만성위염조화십이지장구부궤양조균저우정상대조조(t분별위4.963、6.070,P균＜0.01),RBCICR분별고우정상대조조(t분별위3.262、3.456,P＜0.05혹P＜0.01).HP음성만성위염여HP음성십이지장구부궤양、HP양성만성위염여HP양성십이지장구부궤양분별비교RBCC3hRR화RBCICR차이균무통계학의의(P균＞0.05);만성위염급십이지장구부궤양HP양성RBCC3bRR명현저우HP음성자(P＜0.05혹P＜0.01),RBCICR명현고우HiP음성자(P균＜0.01),HP근제후만성위염화십이지장구부궤양환자RBCC3bRR,분별교치료전명현승고(P＜0.05혹P＜0.01).RBCICR분별교치료전명현강저(P균＜0.01).결론 HP감염、만성위염、십이지장궤양균가강저홍세포면역공능.
Objective To explore changes of the immune function of red blood cells in gastric disease.Methods RBC C3b receptor rosette(RBCC3bRR)and RBC immune complex rosette(RBCICR)were tested in chronic gastritis group(n =103),duodenal ball ulcer group(n =75)and control group(n =30)to evaluate the immune function of RBC.Results RBCC3bRR were(20.83 ± 5.16)％ in the control group,(16.26 ±5.17)％ in the chronic gastritis group and(13.65 ± 5.19)％ in the duodenal ball ulcer group.RBCICR were respectively(7.63 ± 4.09)％,(10.59 + 4.45)％ and(10.04 ± 4.13)％ in these three groups.RBCC3bRR of chronic gastritis and duodenal ball ulcer were lower than control group(P ＜0.0l),while RBCICR were higher than normal control group(P ＜0.05 and P ＜0.01 respectively).There was no significant difference on RBCC3bRR and RBCICR between HP negative chronic gastritis and HP negative duodenal ball ulcer and between HP positive chronic gastritis and HP positive duodenal ball ulcer(P ＞ 0.05).RBCC3bRR of HP positive chronic gastritis and duodenal ball ulcer was significantly lower than that of HP negative(P ＜ 0.05and P ＜ 0.01 respectively),RBCICR significantly higher than that of HP negative(P ＜ 0.01).After HP eradication,RBCC3bRR of patients with chronic gastritis and duodenal ball ulcer was increased significantly (P＜0.05 and P ＜ 0.01 respectively).RBCICR was significantly lower than before treatment(P ＜ 0.01).Conclusion HP infection,chronic gastritis and duodenal ulcer can decrease the immune function of red blood cells.
