CAJ | 학술논문

目的探究粪便潜血检查对于大肠肿瘤的筛检意义.方法纳入北京协和医院消化科门诊行粪便潜血和结肠镜检查并有病理学检查结果的512例患者,以结肠镜及病理检查结果为标准,评价粪便潜血结果的诊断价值.结果 512例患者中,203例粪便潜血结果阳性,353例结肠镜检查正常,115例有各种息肉,病理检查结果示9例高度不典型增生、21例为大肠癌.粪便潜血检查对于大肠腺瘤性息肉检出的灵敏度、特异度、阳性似然比和阴性似然比分别是42.8％、60.9％、1.09和0.93；对大肠癌及高度不典型增生的灵敏度、特异度、阳性似然比和阴性似然比分别是76.6％、62.5％、2.05和0.37.结论在消化内科就诊的患者中,粪便潜血检查对于大肠癌有一定的诊断和筛查意义,有助于临床医生合理临床决策,但尚需前瞻性研究以建立更可靠的大肠癌筛查模型.
목적 탐구분편잠혈검사대우대장종류적사검의의.방법 납입북경협화의원소화과문진행분편잠혈화결장경검사병유병이학검사결과적512례환자,이결장경급병리검사결과위표준,평개분편잠혈결과적진단개치.결과 512례환자중,203례분편잠혈결과양성,353례결장경검사정상,115례유각충식육,병리검사결과시9례고도불전형증생、21례위대장암.분편잠혈검사대우대장선류성식육검출적령민도、특이도、양성사연비화음성사연비분별시42.8％、60.9％、1.09화0.93；대대장암급고도불전형증생적령민도、특이도、양성사연비화음성사연비분별시76.6％、62.5％、2.05화0.37.결론 재소화내과취진적환자중,분편잠혈검사대우대장암유일정적진단화사사의의,유조우림상의생합리림상결책,단상수전첨성연구이건립경가고적대장암사사모형.
Objective To evaluate the application of immunochemical fecal occult blood test for colorectal cancer screening in a gastroenterology clinic. Methods Total 512 outpatients received immunochemical fecal occult blood tests and colonoscopy for screening of colorectal cancer from January 2009 to October 2010 in Gastroenterology Clinic of Peking Union Hospital.The application of occult blood test was retrospectively evaluated using colonoscopy and pathological examination as the gold standard. Results Among 512 patients,203 were found positive for immunochemical fecal occult blood. According to the colonoscopy and histological study,115 patients had polyps,9 with high-grade dysplasia and 21 with colorectal cancer.The sensitivity,specificity,positive likelihood ratio and negative likelihood ratio of fecal occult blood to detect colorectal adenomatous polyps was 42.8％,60.9％,1.09 and 0.93,respectively.And those for detection of colorectal cancer and high-grade dysplasia were 76.6％,62.5％,2.05 and 0.37,respectively.Conclusions Immunochemical fecal occult blood test was useful in the screening for colorectal tumors among gastroenterology clinic patients.More large-scale prospective studies are needed to establish a screening model for colorectal tumors.