CAJ | 학술논문

目的:探讨左氧氟沙星不良反应(ADR)的临床特点.方法:对2006年1月至2008年1问我院门诊及住院患者中出现左氧氟沙星ADR患者70例进行研究,总结分析ADR发生的相关因素、临床表现类型以及治疗和预后.结果:本组年龄<60岁患者有25例(35.71%),年龄≥60岁患者有45例(64.29%);静脉用药发生ADR患者64例(91.43%),口服用药者6例(8.57%);联合用药致ADR 52例(74.29%),单独用药18例(25.71%).本组皮肤反应25例(35.71%),发生率位居首位;其次为消化系统15例(21.43%),全身性损害12例(17.14%)等.所有患者经调整滴速、停药或对症处理后症状均消失.结论:左氧氟沙星ADR发生率日趋升高,临床医护应积极掌握其相关因素、临床表现以及处理措施,以减少ADR的发生.
목적:탐토좌양불사성불량반응(ADR)적림상특점.방법:대2006년1월지2008년1문아원문진급주원환자중출현좌양불사성ADR환자70례진행연구,총결분석ADR발생적상관인소、림상표현류형이급치료화예후.결과:본조년령<60세환자유25례(35.71%),년령≥60세환자유45례(64.29%);정맥용약발생ADR환자64례(91.43%),구복용약자6례(8.57%);연합용약치ADR 52례(74.29%),단독용약18례(25.71%).본조피부반응25례(35.71%),발생솔위거수위;기차위소화계통15례(21.43%),전신성손해12례(17.14%)등.소유환자경조정적속、정약혹대증처리후증상균소실.결론:좌양불사성ADR발생솔일추승고,림상의호응적겁장악기상관인소、림상표현이급처리조시,이감소ADR적발생.
Objective: To investigate the clinical feature of adverse reactions (ADR) on levofloxacin.Method: The datas of 70 cases with adverse reaction of levofloxacin in our hospital from January in 2006 to January in 2008 were analysed to summarize the correlation factors of ADR, clinical manifestations, treatment and prognosis. Result: There were 25 cases (35.71%)who were more than 60 years old and 45 cases (64.29%)who were less than 60 years old. There were 64 cases (91.43% ) with adverse reaction by vein injection and 6 cases (8.57%) with adverse reaction by mouth. There were 52 cases (72.49%) with drug combination and 18 cases (25.71% ) with single drug . The rate of cutaneous reaction was highest in the group and was 35.71% with 25 case.s, and the next were alimentary system with 15 cases(21.43% ), general damage with 12 cases(17.14% ) and so on. The symptom of all cases were vanished by treatment of adjusting droping, discontinuation and so on. Conclusion: The rate of ADR about levofloxacin is increasing quickly, so the clinic doctors and nurses must grasp the correlation factor of ADR, clinical manifestations and treatment to decrease the rate of ADR.