CAJ | 학술논문

细胞因子对急性辐射损伤的治疗作用日益受到重视,尤其是造血生长因子抗辐射作用的研究取得了长足进展.但随着照射剂量的增加,造血干/祖细胞大量死亡及皮肤和胃肠道等非造血系统损伤加重,单一的细胞因子难以逆转严重损伤,因此细胞因子的联合应用成为必然.当前,细胞因子联合治疗急性辐射损伤的研究主要集中于造血生长因子及抗凋亡细胞因子联合应用效果的评价,结果提示,照射后早期细胞因子联合应用是事故性辐射损伤的有效治疗措施.
세포인자대급성복사손상적치료작용일익수도중시,우기시조혈생장인자항복사작용적연구취득료장족진전.단수착조사제량적증가,조혈간/조세포대량사망급피부화위장도등비조혈계통손상가중,단일적세포인자난이역전엄중손상,인차세포인자적연합응용성위필연.당전,세포인자연합치료급성복사손상적연구주요집중우조혈생장인자급항조망세포인자연합응용효과적평개,결과제시,조사후조기세포인자연합응용시사고성복사손상적유효치료조시.
Cytokine-based treatment was well applied to manage acute radiation injury in recentyears.Unfortunately,efficacy of single cytokine was reduced because of multiple organs severe injury causedby hish dose irradiation.It is the rationale for cytokines combination.Anti.radiation efficacy of cytokinescombination were reviewed,especially hematopoietic growth factors and antiappoptic cytokines combined inacute radiation injury management were documented.Emergency cytokines combination would be analternative for acute radiation injury treatment.