CAJ | 학술논문

背景阿片类镇痛药在临床应用有着重要的地位,但有恶心、呕吐、瘙痒、呼吸抑制等不可忽视副作用,长期应用还可产生耐受和依赖.有研究表明,阿片类镇痛药联合应用小剂量的阿片类受体拮抗剂可以明显增强吗啡等阿片类镇痛药的效能,并且同时减弱由其产生的副作用以及耐受和依赖.目的拟通过综述的方式,系统地阐述小剂量纳洛酮联合应用阿片类药物的研究现状以及进展,为今后该方向的研究提供参考,进而启发新的研究思路.内容对阿片类镇痛药联合小剂量纳洛酮应用的基础及临床研究现状和进展以及小剂量纳洛酮增强阿片类镇痛药的镇痛作用、减轻其副作用及耐受和依赖的形成机制进行综述. 趋向从近期研究可见,该方向的研究已不仅限于观察小剂量纳洛酮与吗啡的联合应用所产生的作用,小剂量纳洛酮和其他阿片类药物联合应用的研究也逐步展开,并有越来越多的研究者对二者联合应用所产生的作用机制进行了更为深入的探讨.
배경 아편류진통약재림상응용유착중요적지위,단유악심、구토、소양、호흡억제등불가홀시부작용,장기응용환가산생내수화의뢰.유연구표명,아편류진통약연합응용소제량적아편류수체길항제가이명현증강마배등아편류진통약적효능,병차동시감약유기산생적부작용이급내수화의뢰.목적 의통과종술적방식,계통지천술소제량납락동연합응용아편류약물적연구현상이급진전,위금후해방향적연구제공삼고,진이계발신적연구사로.내용 대아편류진통약연합소제량납락동응용적기출급림상연구현상화진전이급소제량납락동증강아편류진통약적진통작용、감경기부작용급내수화의뢰적형성궤제진행종술. 추향 종근기연구가견,해방향적연구이불부한우관찰소제량납락동여마배적연합응용소산생적작용,소제량납락동화기타아편류약물연합응용적연구야축보전개,병유월래월다적연구자대이자연합응용소산생적작용궤제진행료경위심입적탐토.
Background Opioid analgesics play an important role in clinical settings.However,they also have some side effects,such as nausea,vomiting,pruritus,respiratory depression and so on,which could limit their wide use.Recently,lots of preclinical arid clinical studies have demonstrated that cotreatments with extremely small dose of opioid receptor antagonists can markedly enhance the efficacy of opioid analgesics and simultaneously reduce side effects induced by opioids including tolerance and dependence. Objective This article intends to review the progress in the study of the clinical application of opioid analgesics combined with ultra-low-dose naloxone in order to inspire some new research ideas. Content This article is a review of the progress in the preclinical and clinical studies of combining opioid analgesics and ultra-low-dose naloxone.In the mean time,we set out the probable mechanisms that could account for the enhancement of opioids' analgesic potency and attenuation of side effects,tolerance and dependence,which induced by opioids,during cotreatment with opioids and naloxone. Trend Recently,directions of the research are not limited to observation of the effectiveness in combining ultra -low -dose naloxone and morphine as well as in company with other opioids.More and more researchers are eager to concern about the mechanism of this eotreatment.