中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
5期
4-6
,共3页
乐胜%廖建新%张舜玲%刘志红
樂勝%廖建新%張舜玲%劉誌紅
악성%료건신%장순령%류지홍
细胞因子信号转导抑制因子-3%脓毒症%外周血单个核细胞
細胞因子信號轉導抑製因子-3%膿毒癥%外週血單箇覈細胞
세포인자신호전도억제인자-3%농독증%외주혈단개핵세포
SOCS-3%Sepsis%Peripheral blood mononuclear cells
目的 探讨细胞因子信号转导抑制因子-3(SOCS-3)在脓毒症发病机制中的作用.方法 选择36例脓毒症患者,30例健康志愿者为对照组,应用RT-PCR方法测定SOCS-3在外周血单个核细胞中的表达,并和患者APACHEⅡ评分进行相关分析.结果 SOCS-3在脓毒症组和对照组的外周m单个核细胞中均有表达,脓毒症组较对照组表达显著增加(P<0.001),SOCS-3 mRNA的表达和脓毒症A.PACHEⅡ评分呈负相关,相关系数(r)为0.746(P<0.01).结论 SOCS-3参与了脓毒症的发病过程,SOCS-3的表达在脓毒症患者中可能起着保护作用.
目的 探討細胞因子信號轉導抑製因子-3(SOCS-3)在膿毒癥髮病機製中的作用.方法 選擇36例膿毒癥患者,30例健康誌願者為對照組,應用RT-PCR方法測定SOCS-3在外週血單箇覈細胞中的錶達,併和患者APACHEⅡ評分進行相關分析.結果 SOCS-3在膿毒癥組和對照組的外週m單箇覈細胞中均有錶達,膿毒癥組較對照組錶達顯著增加(P<0.001),SOCS-3 mRNA的錶達和膿毒癥A.PACHEⅡ評分呈負相關,相關繫數(r)為0.746(P<0.01).結論 SOCS-3參與瞭膿毒癥的髮病過程,SOCS-3的錶達在膿毒癥患者中可能起著保護作用.
목적 탐토세포인자신호전도억제인자-3(SOCS-3)재농독증발병궤제중적작용.방법 선택36례농독증환자,30례건강지원자위대조조,응용RT-PCR방법측정SOCS-3재외주혈단개핵세포중적표체,병화환자APACHEⅡ평분진행상관분석.결과 SOCS-3재농독증조화대조조적외주m단개핵세포중균유표체,농독증조교대조조표체현저증가(P<0.001),SOCS-3 mRNA적표체화농독증A.PACHEⅡ평분정부상관,상관계수(r)위0.746(P<0.01).결론 SOCS-3삼여료농독증적발병과정,SOCS-3적표체재농독증환자중가능기착보호작용.
Objective To explore of the role of SOCS-3 in the pathogenesss of sepsis. Methods The expression of SOCS-3 mRNA in peripheral blood mononuelear cells in 36 patients with sepsis and 30 healthy vol-unteers was measured by RT-PCR. The correlation analysis between The expression of SOCS-3 mRNA in periph- end blood mononuelear cells and the septic patient's scores of APACHE 11 was made. Results The expression of SOCS-3 mRNA in peripheral blood mononuclear cells in the sepsis group and the control group were found. The level of SOCS-3 mRNA in the sepsis group were significantly higher than those in the control group ( P <0. 001 ). The expression of SOCS-3 mRNA have a significant negative correlation with the septic patient's scores of APACHE Ⅱ ,the correlation coeffieient(r)was-0.746(P <0.01). Conclusions SOCS-3 have a role in the pathogenesis of sepsis. The expression of SOCS-3 mRNA may have protection in septic patients.
