CAJ | 학술논문

目的探讨血清癌抗原19-9 (CA19-9)水平在胰腺癌可切除性判断中的应用价值.方法采用放射免疫法检测胰腺癌患者血清CA19-9的表达,通过接受者操作特征(ROC)曲线分析确定最佳分界点,通过ROC曲线下面积分析血清CA19-9水平对胰腺癌可切除性判断的临床应用价值.结果可切除性胰腺癌患者CA19-9的水平为(313.6±515.5)kU/L,明显低于不可切除患者的(852.1±865.1)kU/L(P=0.00).根据接受者操作特性曲线,血清CA19-9对胰腺癌可切除性判断的最佳分界点为312.1 kU/L,其灵敏度为56.6％,特异度为73.3％,ROC曲线下面积0.67.结论血清CA19-9水平可作为辅助性手段应用于胰腺癌可切除性的判断.
목적 탐토혈청암항원19-9 (CA19-9)수평재이선암가절제성판단중적응용개치.방법 채용방사면역법검측이선암환자혈청CA19-9적표체,통과접수자조작특정(ROC)곡선분석학정최가분계점,통과ROC곡선하면적분석혈청CA19-9수평대이선암가절제성판단적림상응용개치.결과 가절제성이선암환자CA19-9적수평위(313.6±515.5)kU/L,명현저우불가절제환자적(852.1±865.1)kU/L(P=0.00).근거접수자조작특성곡선,혈청CA19-9대이선암가절제성판단적최가분계점위312.1 kU/L,기령민도위56.6％,특이도위73.3％,ROC곡선하면적0.67.결론 혈청CA19-9수평가작위보조성수단응용우이선암가절제성적판단.
Objective To study the role of preoperative CA19-9 level in predicting resectability of pancreatic cancer.Methods Preoperative CA19-9 levels were determined by radioimmunoassay.The receiver operating characteristic curve was used to determine the cut-off point.The clinical value of the level of CA19-9 as a predictive marker of resectability was evaluated by the area under curve.Results The preoperative CA19-9 levels in the resectahle group was (313.6±515.5) kU/L,which was significantly lower than (852.1± 865.1)kU/L in the unresectable group (P＜0.001).The cut-off point of CA19-9 for predicting pancreatic cancer resectability was 312.1 kU/L,which had a sensitivity of 56.6％ and a specificity of 73.3％.The area under curve was 0.67.Conclusions The preoperative CA19-9 level may be used to predict resectability of pancreatic cancer.