中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2011年
5期
402-405
,共4页
毛雯%董军%李红霞%周敏%国汉邦%王抒%陈文祥%何青
毛雯%董軍%李紅霞%週敏%國漢邦%王抒%陳文祥%何青
모문%동군%리홍하%주민%국한방%왕서%진문상%하청
冠状动脉疾病%脂蛋白,HDL%酯化
冠狀動脈疾病%脂蛋白,HDL%酯化
관상동맥질병%지단백,HDL%지화
Coronary disease%Cholesterol,HDL%Esteriftcation
目的 研究高密度脂蛋白胆固醇酯化速率(FERHDL)与冠心病的相关性,探讨其在冠心病中的临床应用价值.方法 按冠状动脉造影结果将131例研究对象分为冠心病组(n=76)与非冠心病组(n=55),进行临床资料收集、生化指标检测、FERHDL及脂蛋白亚类的测定,分析FERHDL与冠心病的相关性.结果 冠心病组FERHDL明显高于非冠心病组(21.70±8.73比18.65±6.26.P<0.05).FERHDL在非冠心病、单支病变、双支病变、三支病变组间有升高趋势,FERHDL随病变支数增加而逐渐增高,其中非冠心病组和三支病变组比较差异有统计学意义(18.65±6.26比24.00±9.22,P<0.05).FERHDL与甘油三酯(r=0.647,P<0.01)、LDLb-C(r=0.441,P<0.01)呈显著正相关,与HDL-C(r=-0.708,P<0.01)、HDIJ2-C(r=-0.748,P<0.01))呈显著负相关.结论 冠心病患者FERHDL明显高于非冠心病者,FERHDL随冠状动脉病变支数增加而呈增高趋势.FERHDL与HDL和LDL颗粒大小相关.
目的 研究高密度脂蛋白膽固醇酯化速率(FERHDL)與冠心病的相關性,探討其在冠心病中的臨床應用價值.方法 按冠狀動脈造影結果將131例研究對象分為冠心病組(n=76)與非冠心病組(n=55),進行臨床資料收集、生化指標檢測、FERHDL及脂蛋白亞類的測定,分析FERHDL與冠心病的相關性.結果 冠心病組FERHDL明顯高于非冠心病組(21.70±8.73比18.65±6.26.P<0.05).FERHDL在非冠心病、單支病變、雙支病變、三支病變組間有升高趨勢,FERHDL隨病變支數增加而逐漸增高,其中非冠心病組和三支病變組比較差異有統計學意義(18.65±6.26比24.00±9.22,P<0.05).FERHDL與甘油三酯(r=0.647,P<0.01)、LDLb-C(r=0.441,P<0.01)呈顯著正相關,與HDL-C(r=-0.708,P<0.01)、HDIJ2-C(r=-0.748,P<0.01))呈顯著負相關.結論 冠心病患者FERHDL明顯高于非冠心病者,FERHDL隨冠狀動脈病變支數增加而呈增高趨勢.FERHDL與HDL和LDL顆粒大小相關.
목적 연구고밀도지단백담고순지화속솔(FERHDL)여관심병적상관성,탐토기재관심병중적림상응용개치.방법 안관상동맥조영결과장131례연구대상분위관심병조(n=76)여비관심병조(n=55),진행림상자료수집、생화지표검측、FERHDL급지단백아류적측정,분석FERHDL여관심병적상관성.결과 관심병조FERHDL명현고우비관심병조(21.70±8.73비18.65±6.26.P<0.05).FERHDL재비관심병、단지병변、쌍지병변、삼지병변조간유승고추세,FERHDL수병변지수증가이축점증고,기중비관심병조화삼지병변조비교차이유통계학의의(18.65±6.26비24.00±9.22,P<0.05).FERHDL여감유삼지(r=0.647,P<0.01)、LDLb-C(r=0.441,P<0.01)정현저정상관,여HDL-C(r=-0.708,P<0.01)、HDIJ2-C(r=-0.748,P<0.01))정현저부상관.결론 관심병환자FERHDL명현고우비관심병자,FERHDL수관상동맥병변지수증가이정증고추세.FERHDL여HDL화LDL과립대소상관.
Objective To assess the relationship between fractional esterification rate of high density lipoprotein cholesterol(FERHDL)and coronary artery disease.Methods A total of 131 hospitalized patients underwent coronary angiography due to chest pain were included in the study and Datients were divided into CAD group(n=76)and non CAD group(n=55)according to coronary allgiograrn.Clinical and laboratory data including biochemical laboratory,FERHDL and lipid subclasses were analyzed.Results The FERHDL value of CAD group was significantly higher than that of the non CAD group(21.70±8.73 vs.18.65 4±6.26,P<0.05).There was an increased trend of FERHDL with numbers of diseased coronary arteries,significant difference was evidenced between non CAD group and 3-vessel group(18.65±6.26 vs.24.00±9.22,P<0.05).FERHDL was positively correlated with TG(r=0.647,P<0.001).LDLb-C(r=0.441,P<0.001)and negatively correlated with HDL-C(r=-0.708,P<0.001)and HDL2-C(r=-0.748,P<0.001).Conclusion Our data showed that the values of FERHDL were significantly increased in CAD patients and correlated with the severity of the CAD.
