CAJ | 학술논문

目的探讨能否利用损伤的神经远端延长法修复自身缺损。方法观察A组（即刻快速延长10%）、B1组、B2组（神经损伤2周后再行延长，延长率分别为10%、20%）神经耐受程度和恢复情况。结果 A组平均延长（10.00±1.71）%，长度为（4.00±0.74）mm，神经传导速度恢复率 ( 75.71 ± 19.05)%、有髓神经纤维（NNF）再生率为( 72.60±15.76)%；B1分别为（10.50±1.12）%、（4.20±0.44）mm、(82.08± 4.76)%、 (76.22 ± 8.60)%；B2组分别为（21.40±4.03）%、（8.50±1.61）mm、(70.87± 20.86)% 、（ 64.67 ±12.42)%。即刻延长10%和损伤2周后快速延长10%、20%都有一定功能的恢复。结论变性周围神经的即刻延长在10%延长范围内耐受性好，而延长20%仍有再生，可以利用周围神经损伤远端即刻延长的方法来修复神经缺损。
목적탐토능부이용손상적신경원단연장법수복자신결손。방법관찰A조（즉각쾌속연장10%）、B1조、B2조（신경손상2주후재행연장，연장솔분별위10%、20%）신경내수정도화회복정황。결과 A조평균연장（10.00±1.71）%，장도위（4.00±0.74）mm，신경전도속도회복솔 ( 75.71 ± 19.05)%、유수신경섬유（NNF）재생솔위( 72.60±15.76)%；B1분별위（10.50±1.12）%、（4.20±0.44）mm、(82.08± 4.76)%、 (76.22 ± 8.60)%；B2조분별위（21.40±4.03）%、（8.50±1.61）mm、(70.87± 20.86)% 、（ 64.67 ±12.42)%。즉각연장10%화손상2주후쾌속연장10%、20%도유일정공능적회복。결론변성주위신경적즉각연장재10%연장범위내내수성호，이연장20%잉유재생，가이이용주위신경손상원단즉각연장적방법래수복신경결손。
Objective　To investigate the feasibility of repairing defect by segment expansion of the distal injured nerve. Methods　A rabbit median nerve injury model was employed. Twenty-four rabbits weighing 2.5～3.0 kg were used for stretching their wallerian degenerating median nerves with TE. Rabbits were divided into three groups: group A (the distal end of nerves were expanded about 10% immediately after injuries), group B1 (the distal end of nerves were expanded about 10% two weeks later after injuries), group B2 (the distal end of nerves were expanded about 20% two weeks later after injuries). All animals were evaluated by electrophysiological histological methods. Results　The nerves were increased in length. The mean elongation was (4.00±0.74) mm with an elongation rate of (10.00±1.71)%, recovery rate of nerve conduction speed (75.71±19.05)% and the regenerating rate of NNF (72.60±15.76)% in group A; (4.20±0.44) mm with an elongation rate of (10.50±1.12)%, recovery rate of nerve conduction speed (82.08±4.76)% and the regenerating rate of NNF (76.22±8.60)% in group B1; (8.50±1.61) mm with an elongation rate of (21.40±4.03)%, recovery rate of nerve conduction speed (70.87±20.86)% and the regenerating rate of NNF (64.67±12.42)% in group B2. The data showed good function recovery. Conclusion　The ideal range for rapid expansion of the degenerating nerve was 10%. Regeneration still existed in expansion of 20%. The method for rapid expansion of the distal injured peripheral nerve could be used to repair nerve defect.