CAJ | 학술논문

目的通过研究工人锰接触水平与生物材料中锰浓度的关系,探索人群接触锰的早期生物标志物.方法用个体空气采样器采集空气锰,确定时间加权平均暴露剂量,按照不同接触剂量把工人分为对照组、低锰接触组、高锰接触组,测定各组工人发、尿、血清、血细胞及唾液中锰浓度,分析锰接触剂量与生物材料中锰浓度的关系和工龄与生物材料中锰浓度的关系.结果高锰接触组唾液锰为32.17μg/L,发锰为37.39 mg/kg,尿锰为2.50 μg/L,血清锰为29.61 μg/,血细胞锰为14.49μg/L,均明显高于对照组(分别为10.40μg/L、1.60 mg/kg、0.77μg/L、10.30 μg/L、4.56 μg/L),差异均有统计学意义(P<0.01).唾液锰水平与工人当前锰接触剂量呈明显的正相关(r=0.649,P<0.01),与工人接触锰的工龄呈明显的正相关(r=0.404,P<0.01),与工人锰总接触量之间呈明显的正相关(r=0.342,P<0.01);唾液锰水平与血细胞锰、血清锰水平呈明显的正相关(r值分别为0.359,0.303,均P<0.01).结论唾液锰可作为人群锰当前接触和历史接触的生物标志物.
목적 통과연구공인맹접촉수평여생물재료중맹농도적관계,탐색인군접촉맹적조기생물표지물.방법 용개체공기채양기채집공기맹,학정시간가권평균폭로제량,안조불동접촉제량파공인분위대조조、저맹접촉조、고맹접촉조,측정각조공인발、뇨、혈청、혈세포급타액중맹농도,분석맹접촉제량여생물재료중맹농도적관계화공령여생물재료중맹농도적관계.결과 고맹접촉조타액맹위32.17μg/L,발맹위37.39 mg/kg,뇨맹위2.50 μg/L,혈청맹위29.61 μg/,혈세포맹위14.49μg/L,균명현고우대조조(분별위10.40μg/L、1.60 mg/kg、0.77μg/L、10.30 μg/L、4.56 μg/L),차이균유통계학의의(P<0.01).타액맹수평여공인당전맹접촉제량정명현적정상관(r=0.649,P<0.01),여공인접촉맹적공령정명현적정상관(r=0.404,P<0.01),여공인맹총접촉량지간정명현적정상관(r=0.342,P<0.01);타액맹수평여혈세포맹、혈청맹수평정명현적정상관(r치분별위0.359,0.303,균P<0.01).결론 타액맹가작위인군맹당전접촉화역사접촉적생물표지물.
Objective To explore the biomarker of manganese exposure by analyzing the relationship between manganese exposure and concentration in some biomaterials. Methods The air samples were collected through the individual air sample. According to the manganese levels in the air, workers were assigned to control group, low concentration group and high concentration group, and manganese in the hair, urine,serum, blood cell and saliva from different group were measured respectively. The correlations between concentration of external manganese exposure and manganese concentrations in biomaterials, and years of employment and concentrations in biomaterials were analyzed. Results In the high concentration group, saliva manganese was 32.17 μg/L, hair manganese was 37.39 mg/kg, urine manganese was 2.50 μg/L, plasma manganese was 29.61 μg/L, blood manganese was 14.49 μg/L, were higher than those in the control group( 10.40μg/L, 1.60 mg/kg, 0.77 μg/L, 10.30 μg/L, 4.56 μg/L respectively )( P<0.01 ). The manganese concentration in the saliva was significantly correlated with airborne manganese concentration (r=0.649, P<0.01 ), with the years of employment (r=0.404, P<0.01 ), with the total exposure of manganese (r=0.342, P<0.01 ), with the manganese concentration of plasma (r=0.303, P<0.01) and with the manganese concentration in blood cells (r=0.359, P<0.01 ), respectively. Conclusions The concentration of manganese in saliva could work as a biomarker of manganese internal exposure.