CAJ | 학술논문

目的研究不同年龄段月经周期不同时期乳腺ADC的差异,探讨乳腺实质ADC值与年龄及月经周期之间的关系,以指导乳腺MR DWI检查时间的选择.方法采用单次激发平面回波(EPI)技术,b值分别为0、1000 s/mm2,65名健康志愿者按年龄段分成3组:20～29岁21名;30～39岁21名;40～49岁23名.双侧130个乳房分别在月经期、增殖期及分泌期行常规MR平扫及MR DWI检查,测量各期乳头层面乳腺实质平均ADC值,用重复测量资料方差分析比较不同年龄段及月经周期不同时期ADC值之间差异.结果月经期、增殖期及分泌期20～29岁乳腺实质的ADC值[左乳(2.14±0.14)×10-3、(2.03±0.18)×10-3、(2.10±0.19)×10-3 mm2/s;右乳(2.08±0.17)×10-3、(2.02±0.16)×10-3、(2.09±0.17)×10-3 mm2/s] 略高于40～49岁 [左乳(2.02±0.27)×10-3、(1.97±0.25)×10-3、(2.03±0.22)×10-3mm2/s;右乳(1.99±0.29)×10-3、(1.93±0.26)×10-3、(2.03±0.28)×10-3 mm2/s],30～39岁ADC值[左乳(1.94±0.25)×10-3、(1.91±0.21)×10-3、(1.97±0.21)×10-3 mm2/s;右乳(1.97±0.26)×10-3、(1.89±0.25)×10-3、(1.96±0.22)×10-3 mm2/s]最低;月经周期不同时期ADC值差异有统计学意义(F=23.600;P＜0.01);不同年龄段及左右乳ADC值差异无统计学意义(F值分别为1.683、2.248,P值均＞0.05).结论乳腺实质ADC值增殖期下降明显,对各年龄段妇女行乳腺DWI检查应考虑月经周期因素的影响,以减少对乳腺疾病DWI诊断的干扰.
목적 연구불동년령단월경주기불동시기유선ADC적차이,탐토유선실질ADC치여년령급월경주기지간적관계,이지도유선MR DWI검사시간적선택.방법 채용단차격발평면회파(EPI)기술,b치분별위0、1000 s/mm2,65명건강지원자안년령단분성3조:20～29세21명;30～39세21명;40～49세23명.쌍측130개유방분별재월경기、증식기급분비기행상규MR평소급MR DWI검사,측량각기유두층면유선실질평균ADC치,용중복측량자료방차분석비교불동년령단급월경주기불동시기ADC치지간차이.결과 월경기、증식기급분비기20～29세유선실질적ADC치[좌유(2.14±0.14)×10-3、(2.03±0.18)×10-3、(2.10±0.19)×10-3 mm2/s;우유(2.08±0.17)×10-3、(2.02±0.16)×10-3、(2.09±0.17)×10-3 mm2/s] 략고우40～49세 [좌유(2.02±0.27)×10-3、(1.97±0.25)×10-3、(2.03±0.22)×10-3mm2/s;우유(1.99±0.29)×10-3、(1.93±0.26)×10-3、(2.03±0.28)×10-3 mm2/s],30～39세ADC치[좌유(1.94±0.25)×10-3、(1.91±0.21)×10-3、(1.97±0.21)×10-3 mm2/s;우유(1.97±0.26)×10-3、(1.89±0.25)×10-3、(1.96±0.22)×10-3 mm2/s]최저;월경주기불동시기ADC치차이유통계학의의(F=23.600;P＜0.01);불동년령단급좌우유ADC치차이무통계학의의(F치분별위1.683、2.248,P치균＞0.05).결론 유선실질ADC치증식기하강명현,대각년령단부녀행유선DWI검사응고필월경주기인소적영향,이감소대유선질병DWI진단적간우.
Objective To analyze the differences of ADC values in breasts of women of different ages and different menstrual phases, so as to direct the choice of the examination time of MR DWI. MethodsThe breasts of 65 healthy volunteers were scanned with the routine MRI plain scan and DWI in the menstrual, proliferative and secretary phases. DWI was conducted with single shot echo planar imaging technique and b value were 0, 1000 s/mm2. The women were divided into three groups: Group 1(aged 20 to 29 years, 21 cases), Group 2 (aged 30 to 39, 21cases), and Group 3 (aged 40 to 49, 23 cases). The ADC values of all 130 breasts at nipple level in the different phases were measured. The ADC values in the three age groups and in the different menstrual phases were compared using ANOVA. Results The mean ADC values of Group 1 were (2.14±0.14) ×10-3, (2.03±0.18) ×10-3and (2.10±0.19)×10-3mm2/s for left breast, and (2.08±0.17) ×10-3, (2.02±0.16) ×10-3and (2.09±0.17) ×10-3mm2/s for right breast in the menstrual, proliferative and secretary phases. They were slightly higher than Group 3, which were (2.02±0.27) ×10-3, (1.97±0.25) ×10-3and (2.03±0.22)×10-3 mm2/s for left breast and (1.99±0.29) ×10-3, (1.93±0.26) ×10-3and (2.03±0.28)×10-3 mm2/s for right breast. The mean ADC values of Group 2 [left breast: (1.94±0.25) ×10-3, (1.91±0.21) ×10-3and (1.97±0.21)×10-3 mm2/s ; right breast: (1.97±0.26)×10-3, (1.89±0.25)×10-3and (1.96±0.22)×10-3 mm2/s) were the lowest among the three age groups. There were significant differences in different menstrual phases (F= 23.600, P＜0.01), but no statistical difference was found among the three age groups or between left breasts and right breasts (F= 1.683, 2.248;P＞0.05).Conclusions The mean ADC values of breasts decrease markedly in the proliferative phase.The effects of the menstrual cycle on the breast ADC values should be considered in the evaluation of breast diseases with DWI.