CAJ | 학술논문

目的探讨Th1,Th2,Th17,调节性T细胞分化及相关细胞因子在类风湿关节炎(RA)发病机制的相关性.方法选取71例RA患者作为试验对象,并根据DAS28评分,分为高、中、低活动组,采集试验对象及健康对照组(18名)外周血,采用流式细胞术分别检测Th1,Th2,Th17及调节性T细胞在RA患者不同活动组的百分率.统计学方法采用t检验.结果 RA患者外周血Th1[(6.2±4.5)％],Th17[(1.1±0.9)％],调节性T细胞[(1.8±1.2)％]所占外周细胞比例与健康对照组比较差异有统计学意义(P＜0.05)；且Th1,Th17,调节性T细胞比例与DAS28评分有关.结论 Th1,Th17细胞参与疾病的发生、发展；Th2、调节性T细胞可能阻止疾病的进一步发展.
목적 탐토Th1,Th2,Th17,조절성T세포분화급상관세포인자재류풍습관절염(RA)발병궤제적상관성.방법 선취71례RA환자작위시험대상,병근거DAS28평분,분위고、중、저활동조,채집시험대상급건강대조조(18명)외주혈,채용류식세포술분별검측Th1,Th2,Th17급조절성T세포재RA환자불동활동조적백분솔.통계학방법채용t검험.결과 RA환자외주혈Th1[(6.2±4.5)％],Th17[(1.1±0.9)％],조절성T세포[(1.8±1.2)％]소점외주세포비례여건강대조조비교차이유통계학의의(P＜0.05)；차Th1,Th17,조절성T세포비례여DAS28평분유관.결론 Th1,Th17세포삼여질병적발생、발전；Th2、조절성T세포가능조지질병적진일보발전.
Objective To explore the correlation between Th1,Th2,Th17,and Treg cells differentiation and related cytokines in patients with rheumatoid arthritis (RA).Methods Seventy-one patients with active RA were enrolled in this study.They were divided into low,moderate and high disease activity groups according to disease activity score (DAS28).The frequencies of Th1,Th2,Th17,and Treg cells in the peripheral blood of RA patients group (n=71) and healthy conlrol group (n=18) were determined by flow cytometry.T test was used for statistical analysis.Results Significant difference could be detected between the proportions of Th1 [ (6.2±4.5)％],Th17 [ (1.1±0.9)％] and Treg [(1.8±1.2)％] cells in the peripheral blood of RA patients and the control group (P＜0.05),and there was correlation between proportions of these three kinds of cell and the DAS28.Conclusion Th1 and Th 17 cells may promote the development of RA disease,but Th2 and Treg cells could prevent further development of RA disease.