CAJ | 학술논문

目的探讨红花注射液对撞击所致心肌挫伤的治疗作用机制.方法选取30只健康日本大耳兔,按随机数字表法分为心肌挫伤对照组(对照组)和红花注射液治疗组(红花组).每组15只.用BIM -Ⅱ型生物撞击机制备兔严重心肌挫伤模型.分别于伤前10 min、伤后10,30min、1,3,6,l2,24h各时相点采集两组颈总动脉血,检测血栓素A2(TXA2)、前列环素(PGI2)的浓度；于伤后24h解剖观察心脏大体和显微病理改变.结果对照组伤后血浆PGI2浓度较伤前明显下降,TXA2浓度较伤前明显升高,形态学检查心肌组织损伤较重；红花组伤后血浆PGI2浓度降低幅度和TXA2浓度升高幅度较对照组均不明显,心肌组织损伤也较对照组明显减轻；血浆血栓素B2(TXB2)/6-酮-前列腺素Fla(6 - Keto - PGFla)比值伤后红花组明显低于对照组(P＜0.05).结论红花注射液对心肌挫伤有治疗作用,其机制可能与红花注射液能升高血浆 PGI2浓度、降低TXA2浓度有关.
목적 탐토홍화주사액대당격소치심기좌상적치료작용궤제.방법 선취30지건강일본대이토,안수궤수자표법분위심기좌상대조조(대조조)화홍화주사액치료조(홍화조).매조15지.용BIM -Ⅱ형생물당격궤제비토엄중심기좌상모형.분별우상전10 min、상후10,30min、1,3,6,l2,24h각시상점채집량조경총동맥혈,검측혈전소A2(TXA2)、전렬배소(PGI2)적농도；우상후24h해부관찰심장대체화현미병리개변.결과 대조조상후혈장PGI2농도교상전명현하강,TXA2농도교상전명현승고,형태학검사심기조직손상교중；홍화조상후혈장PGI2농도강저폭도화TXA2농도승고폭도교대조조균불명현,심기조직손상야교대조조명현감경；혈장혈전소B2(TXB2)/6-동-전렬선소Fla(6 - Keto - PGFla)비치상후홍화조명현저우대조조(P＜0.05).결론 홍화주사액대심기좌상유치료작용,기궤제가능여홍화주사액능승고혈장 PGI2농도、강저TXA2농도유관.
Objective To investigate the mecbanism of safflor injection treating myocardial contusion following thoracic impact.Methods Thirty healthy Japan big-ear rabbits were randomly assigned to the myocardial contusion control group (control group,n =15) and safflor injection group (safflor group,n =15).The rabbits with severe myocardial contusion were induced by BIM-Ⅱ Horizontal Bioimpact Machine.Blood samples were taken from common carotid artery of both groups to measure the levels of plasma thromboxance A2 (TXA2) and prostaglandin I2 ( PGI2 ) at 10 minutes before impact and at t0 minutes,30 minutes,1,3,6,12 and 24 hours after impact.Rabbits were dissected to observe the gross and micropathological changes of the hern at 24 hours after impact.Results The control group showed a distinct falling of plasma PGI2 concentration and a significant increase of plasma TXA2 concentration in the early period after severe myocardial contusion.The morphological observation revealed severe myocardial tissue injury as well.However,the safflor group showed insignificant variation pertaining to the reduction of plasma PGI2 concentration and increase of plasma TXA2 concentration,but obvious alleviation of myocardial tissue injury,as compared with the control group.Meanwhile,the ratio of TXB2 to 6- Ketoprostaglandin Fla (6-Keto-PGFla) in the safflor group was lower than that of the control group (P ＜0.05).Conclusion Safflor injection has therapeutic effect on myocardial contusion by elevating the concentration of plasma PGI2 and decreasing the concentration of plasma TXA2 in the early period after severe myocardial contusion.