CAJ | 학술논문

神经病理性疼痛是由神经系统损伤所致的一种慢性疼痛,发病机制复杂.已经证实异位放电是痛觉异常的电生理学基础,并且离子通道改变是形成异常放电的主要原因.就现有文献报道的感觉神经元中一些重要离子通道在神经病理性疼痛中的变化作一简单综述.
신경병이성동통시유신경계통손상소치적일충만성동통,발병궤제복잡.이경증실이위방전시통각이상적전생이학기출,병차리자통도개변시형성이상방전적주요원인.취현유문헌보도적감각신경원중일사중요리자통도재신경병이성동통중적변화작일간단종술.
Neuropathic pain is a chronic pain caused by nervous system lesions, which pathogenesis is complex. It has been shown that ectonic discharge is the electrophysiologic base of allodynia, and the change of ion channels is a major cause of ectonic discharge. This review focuses on changes of some important ion channels in neuropathic pain reported in available literature.