国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2008年
11期
803-806
,共4页
微RNAs%基因沉默%肿瘤%基因表达
微RNAs%基因沉默%腫瘤%基因錶達
미RNAs%기인침묵%종류%기인표체
MicroRNAs%Gene silieneing%Neoplasms%Gene expression
微小RNA(miRNA)是一类小分子的非编码调控的单链RNA,它参与有机体的生长、发育等多种生理过程.近年来研究表明肿瘤组织具有不同的miRNA表达,异常表达的miRNA影响了肿瘤细胞的发生、进展、分化、转移和复发.miRNA的不同表达不仅有助于肿瘤组织的诊断,而且可以指导预后.针对miRNA为靶点的动物学研究也发现,干扰某种miRNA表达可以减小肿瘤体积,抑制腹膜转移而发挥治疗作用.
微小RNA(miRNA)是一類小分子的非編碼調控的單鏈RNA,它參與有機體的生長、髮育等多種生理過程.近年來研究錶明腫瘤組織具有不同的miRNA錶達,異常錶達的miRNA影響瞭腫瘤細胞的髮生、進展、分化、轉移和複髮.miRNA的不同錶達不僅有助于腫瘤組織的診斷,而且可以指導預後.針對miRNA為靶點的動物學研究也髮現,榦擾某種miRNA錶達可以減小腫瘤體積,抑製腹膜轉移而髮揮治療作用.
미소RNA(miRNA)시일류소분자적비편마조공적단련RNA,타삼여유궤체적생장、발육등다충생리과정.근년래연구표명종류조직구유불동적miRNA표체,이상표체적miRNA영향료종류세포적발생、진전、분화、전이화복발.miRNA적불동표체불부유조우종류조직적진단,이차가이지도예후.침대miRNA위파점적동물학연구야발현,간우모충miRNA표체가이감소종류체적,억제복막전이이발휘치료작용.
MicroRNAs are a class of small(about 20-24 nueleotides),endogenous,noneoding RNA molecules that regulate a wide array of physiologic processes,such as growth and developmenL In recent years,some researches show that the tissues from tumors have aberrant mieroRNA profiling compared with normal tis-sues.The abnormal miemRNA profiling can affect the genesis,proliferation,differentiation,metastasis and recur-renee of tumors.The different expressions of microRNA Can not only help for the diagnosis of tumors,but also evaluate the prognosis of tumors.Disturbing several miemRNA expressions can decrease the volumes of tumor and inhibit the peritoneal metastasis 80 as to treat the tumor by using anti-mieroRNA drugs in animal expedments.
