中华航海医学与高气压医学杂志
中華航海醫學與高氣壓醫學雜誌
중화항해의학여고기압의학잡지
CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
2008年
3期
160-162
,共3页
吕礁%施云星%王石%周国中%曾晓虹%刘长云%覃林花%季兴英%郝杰%李永平
呂礁%施雲星%王石%週國中%曾曉虹%劉長雲%覃林花%季興英%郝傑%李永平
려초%시운성%왕석%주국중%증효홍%류장운%담림화%계흥영%학걸%리영평
胃肠电%胃食管反流%航行%运动病
胃腸電%胃食管反流%航行%運動病
위장전%위식관반류%항행%운동병
Gastrointestinal bioelectricity%Castroesophageal reflux%Sailing%Motion sickness
目的 观察运动前后及服药后消化道症状及胃肠电各参数变化情况,为寻找相应的防治措施提供理论依据.方法 健康志愿者22名(男21名,女1名),测试前3 d停服各种胃肠动力药.将烧心、反酸、反食及胸骨后疼痛等症状程度和频度的积分(Sc)作为症状指标,同时用WCDF-4b胃肠电分析记录仪,测定航行前、航行中及口服西沙比利2 h后的Sc积分(最高24分),以及主频率(Fp)、频率不稳定系数(FIC)、主功率不稳定系数(DPIC)、主频率不稳定系数(DFIC)、幅度不稳定系数(VIC)等的变化.结果 (1)航行前与航行中相比、航行中与服药后相比,Sc差异均有统计学意义(分别为t=7.8636、3.0849,均为P＜0.05).(2)航行中,DPIC、DFIC、VIC均高于航行前(分别为t=3.2424、2.5325、2.4743,均为P＜0.05),服药后DFIC则低于航行中(t=2.3930,P＜0.05).结论 人体处于大风浪中航行时,消化道症状不仅明显多于航行前,而且其胃肠电分析中各不稳定系数明显升高,胃肠节律出现紊乱,胃食管运动功能发生障碍,出现较多的消化道症状,故有必要用药物加以干预.根据这些参数的变化有助于寻找到更加理想的抗运动病药物.
目的 觀察運動前後及服藥後消化道癥狀及胃腸電各參數變化情況,為尋找相應的防治措施提供理論依據.方法 健康誌願者22名(男21名,女1名),測試前3 d停服各種胃腸動力藥.將燒心、反痠、反食及胸骨後疼痛等癥狀程度和頻度的積分(Sc)作為癥狀指標,同時用WCDF-4b胃腸電分析記錄儀,測定航行前、航行中及口服西沙比利2 h後的Sc積分(最高24分),以及主頻率(Fp)、頻率不穩定繫數(FIC)、主功率不穩定繫數(DPIC)、主頻率不穩定繫數(DFIC)、幅度不穩定繫數(VIC)等的變化.結果 (1)航行前與航行中相比、航行中與服藥後相比,Sc差異均有統計學意義(分彆為t=7.8636、3.0849,均為P＜0.05).(2)航行中,DPIC、DFIC、VIC均高于航行前(分彆為t=3.2424、2.5325、2.4743,均為P＜0.05),服藥後DFIC則低于航行中(t=2.3930,P＜0.05).結論 人體處于大風浪中航行時,消化道癥狀不僅明顯多于航行前,而且其胃腸電分析中各不穩定繫數明顯升高,胃腸節律齣現紊亂,胃食管運動功能髮生障礙,齣現較多的消化道癥狀,故有必要用藥物加以榦預.根據這些參數的變化有助于尋找到更加理想的抗運動病藥物.
목적 관찰운동전후급복약후소화도증상급위장전각삼수변화정황,위심조상응적방치조시제공이론의거.방법 건강지원자22명(남21명,녀1명),측시전3 d정복각충위장동력약.장소심、반산、반식급흉골후동통등증상정도화빈도적적분(Sc)작위증상지표,동시용WCDF-4b위장전분석기록의,측정항행전、항행중급구복서사비리2 h후적Sc적분(최고24분),이급주빈솔(Fp)、빈솔불은정계수(FIC)、주공솔불은정계수(DPIC)、주빈솔불은정계수(DFIC)、폭도불은정계수(VIC)등적변화.결과 (1)항행전여항행중상비、항행중여복약후상비,Sc차이균유통계학의의(분별위t=7.8636、3.0849,균위P＜0.05).(2)항행중,DPIC、DFIC、VIC균고우항행전(분별위t=3.2424、2.5325、2.4743,균위P＜0.05),복약후DFIC칙저우항행중(t=2.3930,P＜0.05).결론 인체처우대풍랑중항행시,소화도증상불부명현다우항행전,이차기위장전분석중각불은정계수명현승고,위장절률출현문란,위식관운동공능발생장애,출현교다적소화도증상,고유필요용약물가이간예.근거저사삼수적변화유조우심조도경가이상적항운동병약물.
Objective To observe the changes of alimentary tract symptom and gastrointestinal bioelectricity before and after motion as well as after taken the medicine in sailing state to provide theory bases on prevention and cure measure for motion sickness. Methods Healthy volunteer was 22 cases, among whom there was one female. They stopped taking gastrointestinal dynamia drug three days before test. The integration (Sc) of degree and frequency of some symptoms including heartburn, acid reflux, food reflux and abdominal discomfort was regarded as test index. The following indexes were examined by WCDF-4b electrogastroentero analysis instrument : the Sc of before sailing, during sailing and two hour after taken the medicine as. well as master frequency ( Fp), frequency instability coefficient ( FIG), master power instability coefficient ( DPIC ) , master frequency instability coefficient ( DFIC ) and amplitude instability coefficient ( VIC). Results (1 ) There were statistically significant differences between before and during sailing as well as during sailing and two hours after taken the medicine in the Sc(t=7.8636,3.0849; P<0.05). (2)The values of DPIC, DFIC and VIC were higher during sailing than before sailing (t = 3. 2424, 2. 5325, 2. 4743; P < 0. 05 ). The value of DFIC was lower after taken the medicine than during sailing (t = 2. 3930, P < 0. 05). Conclusions During sailing especially violent pathogenic wind wave, the symptoms in alimentary canal in person were much more than before sailing, and all instable coefficients of electrogastroentero analysis significantly increased, gastrointestinal rhythm and esophagus dynamical dysfunction disordered in patients. The present results indicated that it was necessary to use medicine to interfere. These parametric changes conduce to find out better motion sickness drug.
