CAJ | 학술논문

细胞间黏附分子-1与肝癌的发生、发展和转移过程密切相关.多种炎症因子及刺激通过核因子-κB信号通路对细胞间黏附分子-1的表达产生影响.在炎症阶段、肝硬化期和肿瘤期,细胞间黏附分子-1通过不同表达对细胞产生不同作用,促进肿瘤的发生与转移.细胞间黏附分子-1对AFP阴性或可疑阳性的肝细胞癌有早期诊断意义,是评估肝癌转移及预后的生物标记.许多治疗肝癌的新方法基于在不同层面对细胞间黏附分子-1的影响进而产生抗肿瘤作用.
세포간점부분자-1여간암적발생、발전화전이과정밀절상관.다충염증인자급자격통과핵인자-κB신호통로대세포간점부분자-1적표체산생영향.재염증계단、간경화기화종류기,세포간점부분자-1통과불동표체대세포산생불동작용,촉진종류적발생여전이.세포간점부분자-1대AFP음성혹가의양성적간세포암유조기진단의의,시평고간암전이급예후적생물표기.허다치료간암적신방법기우재불동층면대세포간점부분자-1적영향진이산생항종류작용.
Intercellular adhesion molecule -1 is closely related to the occurrence,development and me mastasis of liver cancer.A variety of inflammatory cytokines and stimulus effect on the expression of Intereclluar adhesion molecule-1 through Nuclear factor-kappa B signal transduction pathways.In the stage of inflammation,hepatocirrhusis and tumor,Intercelluar adhesion molecule-1 is expressed differently,and makes different effects on different cells,to promote the occurrence and metastasis of tumor.Diagnostic significance of Intercelluar adhesion molecule1 is to diagnose hepatocellular carcinoma with AFP-negative or suspected-positive more early.What's more it can prognosticate the metastasis and prognosis of liver cancer as a biomarker.Many new treatments of liver cancer are based on the effects on Intercelluar adhesion molecule-1 in different levels producing antitumor function.