CAJ | 학술논문

目的：建立尿液中加替沙星的含量测定方法。方法：采用紫外分光光度法，以333nm作为检测波长。通过5名健康志愿者实验，考察尿药中加替沙星的排泄量。结果：尿液中加营沙星在1．00～36．00μg／mL浓度范围内线性关系良好（r=0．9998），平均方法回收率为98．1％，RSD为2．87％；平均萃取回收率为9514％，RSD为3．66％，24h排泄量在44-3％～69．6％。结论：该方法简单、快速、灵敏、准确，可推广使用。
목적：건립뇨액중가체사성적함량측정방법。방법：채용자외분광광도법，이333nm작위검측파장。통과5명건강지원자실험，고찰뇨약중가체사성적배설량。결과：뇨액중가영사성재1．00～36．00μg／mL농도범위내선성관계량호（r=0．9998），평균방법회수솔위98．1％，RSD위2．87％；평균췌취회수솔위9514％，RSD위3．66％，24h배설량재44-3％～69．6％。결론：해방법간단、쾌속、령민、준학，가추엄사용。
Objective： To determine the content of Gatifloxacin in urine with ultraviolet speetrophotometry method. Methods： Urine samples from 5 healthy volunteers were collected .The contents of Gatifloxacin in urine were determined by ultraviolet speetrophotnmetry with the detective wavelength of 333nm. Results： Data have shown a good linear relation between Gatifloxacin cotent and absorbance （r =0.999 8）with the Gatifloxacin concentration in 1.00 to 36.00 μg/ml. The average recoveiy was 98.1% with RSD 2.87%; the average extraction recovery was 95.4% with RSD 3.66%, excretion rate in 24 hours was 44.3%-69.6%. Conclusion： The simple, quick, sensitive and accurate method applied here is worthy of promoting in Gatifloxacin determine in urine.