CAJ | 학술논문

本研究以高原鼢鼠为材料,运用组织学和免疫组织化学研究方法,对营地下生活的高原鼢鼠经过低氧处理后延髓中Fos蛋白的表达情况进行研究.结果表明,经过低氧适应后,高原鼢鼠延髓中Fos蛋白表达的量随低氧浓度的降低而升高,较常氧组,低氧浓度14.1%7天组、低氧浓度10.5%7天组、低氧浓度6.5%1天组Fos蛋白的表达量分别升高了3.67倍、7.76倍和33.38倍.同时在一定的低氧浓度中,Fos蛋白的表达量随低氧时程的延长而降低.高原鼢鼠在低氧浓度14.1%以下,7天低氧适应延髓中Fos蛋白表达量低于4天适应的表达量（P〉0.05）;同时在低氧浓度10.5%下,7天低氧适应延髓中Fos蛋白表达量极显著低于4天适应的表达量（P〈0.01）.由此可见,高原鼢鼠能够适应低氧环境,在低氧刺激下,神经系统反应敏感,能够主导机体各系统的低氧反应.
본연구이고원분서위재료,운용조직학화면역조직화학연구방법,대영지하생활적고원분서경과저양처리후연수중Fos단백적표체정황진행연구.결과표명,경과저양괄응후,고원분서연수중Fos단백표체적량수저양농도적강저이승고,교상양조,저양농도14.1%7천조、저양농도10.5%7천조、저양농도6.5%1천조Fos단백적표체량분별승고료3.67배、7.76배화33.38배.동시재일정적저양농도중,Fos단백적표체량수저양시정적연장이강저.고원분서재저양농도14.1%이하,7천저양괄응연수중Fos단백표체량저우4천괄응적표체량（P〉0.05）;동시재저양농도10.5%하,7천저양괄응연수중Fos단백표체량겁현저저우4천괄응적표체량（P〈0.01）.유차가견,고원분서능구괄응저양배경,재저양자격하,신경계통반응민감,능구주도궤체각계통적저양반응.
Myospalax baileyi lives underground all its life,where is relatively short of oxygen.In the present experiment,we studied Fos expression content of the medulla using histological and immunohistochemistry method.The results are as follows： Fos expression content of intermittent hypoxic rats were increased significantly as compared with normoxic control rats and presented linear changes.This result suggests that Myospalax cansus is adapted to hypoxic habitats and has stronger ability of hypoxic adaptation.And its nervous system is susceptible of hypoxia,which can lead the hypoxic reflection of all system in Myospalax cansus.