北京医学
北京醫學
북경의학
BEIJING MEDICAL JOURNAL
2010年
4期
313-315
,共3页
宽脉压%炎性因子%哇巴因
寬脈壓%炎性因子%哇巴因
관맥압%염성인자%왜파인
Higher-pulse press(H-PP)%Inflammatory factor%Endogenous ouabain(EO)
目的 探讨炎症、内源性哇巴因(EO)在宽脉压形成中的作用.方法 入选65位受试者,均为老年高血压病患者,对入选者进行药物洗脱.根据受试者24h动态平均脉雎(PP)分为二组,即≥60mmHg 组及＜60mmHg组.测定两组患者血清白介素-6(IL--6)、高敏C反应蛋白(ha-CRP)及哇巴因(EO).比较两组检测指标的差异.结果 PP≥60mmHg组IL-6[(30.1±5.0)pg/L]、ha-CRP[(5.4±2.0)mg/L]、EO[(0.79±0.12)μg/L]均显著高于PP＜60mmHg组各测量值[(20.3±3.6)pg/L、(4.2±1.2)mg/L、(0.70±0.12)μg/L,P＜0.05].结论 炎症反应、EO可能参与了宽脉压的形成.
目的 探討炎癥、內源性哇巴因(EO)在寬脈壓形成中的作用.方法 入選65位受試者,均為老年高血壓病患者,對入選者進行藥物洗脫.根據受試者24h動態平均脈雎(PP)分為二組,即≥60mmHg 組及＜60mmHg組.測定兩組患者血清白介素-6(IL--6)、高敏C反應蛋白(ha-CRP)及哇巴因(EO).比較兩組檢測指標的差異.結果 PP≥60mmHg組IL-6[(30.1±5.0)pg/L]、ha-CRP[(5.4±2.0)mg/L]、EO[(0.79±0.12)μg/L]均顯著高于PP＜60mmHg組各測量值[(20.3±3.6)pg/L、(4.2±1.2)mg/L、(0.70±0.12)μg/L,P＜0.05].結論 炎癥反應、EO可能參與瞭寬脈壓的形成.
목적 탐토염증、내원성왜파인(EO)재관맥압형성중적작용.방법 입선65위수시자,균위노년고혈압병환자,대입선자진행약물세탈.근거수시자24h동태평균맥저(PP)분위이조,즉≥60mmHg 조급＜60mmHg조.측정량조환자혈청백개소-6(IL--6)、고민C반응단백(ha-CRP)급왜파인(EO).비교량조검측지표적차이.결과 PP≥60mmHg조IL-6[(30.1±5.0)pg/L]、ha-CRP[(5.4±2.0)mg/L]、EO[(0.79±0.12)μg/L]균현저고우PP＜60mmHg조각측량치[(20.3±3.6)pg/L、(4.2±1.2)mg/L、(0.70±0.12)μg/L,P＜0.05].결론 염증반응、EO가능삼여료관맥압적형성.
Objective To study the effects of inflammation and endogenous ouabain (EO) on the formation of high pulse press (PP). Methods Sixty-five hypertensive patients were selected. After wash out, the subjects were divided into two groups based on the average ambulatory pulse pressure of 24h. One group included patients whose PP was equal to or higher than 60 mmHg (n=31), the other group were patients with PP＜60 mmHg (n=34). The serum C-reactive protein,IL-6 and EO in all cases were measured. All the parameters before and after the therapy were compared. The data were analyzed with SPSS11.5. Results The serum levels of C-reactive protein, IL-6 and EO were significantly higher in PP≥60 mmHg group than that in the PP＜60 mmHg group. Conclusions Inflammation and EO are probably involved in the development of high pulse-pressure.
