CAJ | 학술논문

目的研究体重在女性儿童青少年青春发育过程中的作用及可能的机制.方法采用横断面调查和纵向随访结合的方式,对288名5～16岁健康女性儿童青少年进行连续4年的随访,观察第2性征发育、身高、体重、体脂比例,测定血瘦素和胰岛素样生长因子-1(IGF-1)水平,分析青春发育始动和月经初潮的影响因素.结果女性儿童青少年血瘦素水平从13岁开始显著增加,至16岁达峰值;IGF-1与青春发育始动年龄相关;体重指数和体脂比例对青春发育始动无显著影响,但与月经初潮年龄呈负相关.结论体重可能参与了青少年女性月经初潮的发生.
목적 연구체중재녀성인동청소년청춘발육과정중적작용급가능적궤제.방법 채용횡단면조사화종향수방결합적방식,대288명5～16세건강녀성인동청소년진행련속4년적수방,관찰제2성정발육、신고、체중、체지비례,측정혈수소화이도소양생장인자-1(IGF-1)수평,분석청춘발육시동화월경초조적영향인소.결과 녀성인동청소년혈수소수평종13세개시현저증가,지16세체봉치;IGF-1여청춘발육시동년령상관;체중지수화체지비례대청춘발육시동무현저영향,단여월경초조년령정부상관.결론 체중가능삼여료청소년녀성월경초조적발생.
Objective To investigate the possible effects and roles of bodyweight on the puberty onset in adolescent girls.Methods Totally 288 Chinese female children and adolescent girls aged 5 to 16 were followed up yearly for four consecutive years.The height,bodyweight,fat percentage,sexual characteristics,and the serum levels of leptin and insulin-like growth factor-1(IGF-1)were studied to analyze the influential factors of puberty onset and age of monarche.Results The serum level of leptin elevated signifanctly from age 13[(9.23±1.25)μg/L]and reached peak at age 16[(13.19±1.45)μg/L].IGF-1 significantly correlated with the timing of puberty onset r=0.292.P=0.016).BMI and fat percentage had no significant effects on the onset of puberty,but were negatively correlated with the age of menarche(r=-0.323,P=0.037;r=-0.298,P=0.038,respectively).Conclusion Bodyweight may have effect on puberty onset in female addescents.