CAJ | 학술논문

用于逻辑调控基因表达分子自动机的研究是DNA计算的重要研究领域.文中将脱氧核酶技术应用于DNA计算研究当中,利用脱氧核酶的特性,特别是可以作为反义药物的特点,作为构建分子自动机的主要材料,设计了调控基因H-ras表达的DNA计算模型,而且模型也可适用于其它过表达基因的调控.结合DNA计算具备的高度并行性和智能性的优点,该模型为DNA计算在基因表达调控方面的应用做了进一步探索.
용우라집조공기인표체분자자동궤적연구시DNA계산적중요연구영역.문중장탈양핵매기술응용우DNA계산연구당중,이용탈양핵매적특성,특별시가이작위반의약물적특점,작위구건분자자동궤적주요재료,설계료조공기인H-ras표체적DNA계산모형,이차모형야가괄용우기타과표체기인적조공.결합DNA계산구비적고도병행성화지능성적우점,해모형위DNA계산재기인표체조공방면적응용주료진일보탐색.
A molecular computer for logical control of gene expression is an essential research field of DNA computing.In this paper,with its characteristic especially being antisense medica-tion,DNAzyme technique is used in construction of DNA computing model as basis material.Furthermore,a DNA computing model is designed to control H-ras gene expression,and this model also has potential to control other over expressed genes.Benefited from the massive paral-lelism and intelligence feature of DNA computing,this model explores further application of DNA computing to control of gene expression.