CAJ | 학술논문

胚胎干细胞是存在于胚胎发育早期阶段,具有自我更新和多分化潜能的于细胞.是组成机体各种组织器官的起源细胞.在一定条件下,其在体外可以保持未分化状态,长期存活无限繁殖.有关胚胎干细胞在动物疾病模犁中治疗作用的研究,尤其是在小鼠胚胎千细胞的研究,已趋于成熟.在此基础上,人们开始尝试将人类胚胎干细胞用于临床治疗各种疾病,探讨其可行性和安全性等问题.目前胚胎千细胞已经应用在治疗糖尿病,帕金森及心血管损伤等各种疾病中,虽然有很多技术问题和社会伦理问题需要解决与克服,相信随着胚胎干细胞定向分化机制的逐渐完善,优化培养体系的建立,致瘤性的解决,该细胞疗法作为一种新的治疗方式,将适用于临床使用.
배태간세포시존재우배태발육조기계단,구유자아경신화다분화잠능적우세포.시조성궤체각충조직기관적기원세포.재일정조건하,기재체외가이보지미분화상태,장기존활무한번식.유관배태간세포재동물질병모리중치료작용적연구,우기시재소서배태천세포적연구,이추우성숙.재차기출상,인문개시상시장인류배태간세포용우림상치료각충질병,탐토기가행성화안전성등문제.목전배태천세포이경응용재치료당뇨병,파금삼급심혈관손상등각충질병중,수연유흔다기술문제화사회윤리문제수요해결여극복,상신수착배태간세포정향분화궤제적축점완선,우화배양체계적건립,치류성적해결,해세포요법작위일충신적치료방식,장괄용우림상사용.
Embryonic stem cell (ESC) is a kind of stem cell with self-renewal capability and developmental luripotency,which is at the early stage of embryonic development,and it is the original cell of various kinds of tissue and organ.Under certain conditions,ESCs can maintain an undifferentiated state,long-term surviving and infinite breeding state in vitro.The research of tberapeutic effect of ESCs in animal disease model,especially in ouse,has made great progress.On the basis of this research,researchers attempt to use ESCs for the clinical therapy of various diseases,and investigate the feasibility and security of this kind of therapy.Currently ESCs have been used in the therapy of diabetes mellitus,Parkinson's disease and cardiovascular injury.Even though many problems of technique and ethics should be done,we believe that ESC therapy will be a promising method and used in linical practice if we make clear the mechanism of ESC directional differentiation,establish an optimal culture system,and solve the problem of oncogenicity.