生理学报
生理學報
생이학보
ACTA PHYSIOLOGICA SINICA
2007年
4期
487-494
,共8页
周文良%左武麟%阮晔纯%王喆%杜建阳%熊原%陈小章
週文良%左武麟%阮曄純%王喆%杜建暘%熊原%陳小章
주문량%좌무린%원엽순%왕철%두건양%웅원%진소장
ATP%附睾%输精管%上皮分泌%平滑肌收缩
ATP%附睪%輸精管%上皮分泌%平滑肌收縮
ATP%부고%수정관%상피분비%평활기수축
ATP%epididymis%vas deferens%epithelial secretion%smooth muscle contraction
胞外ATP除了能广泛作为神经递质外,还被认为是一种旁分泌或自分泌因子.ATP从男性生殖道中的精子或上皮细胞中释放,在调节各种生殖生理功能中起多种作用.本文综述了ATP调节附睾上皮细胞阴离子分泌的信号通路,阐述了ATP对依赖上皮细胞的输精管平滑肌收缩的调节机制,讨论了ATP在男性生殖道中的功能和作用.
胞外ATP除瞭能廣汎作為神經遞質外,還被認為是一種徬分泌或自分泌因子.ATP從男性生殖道中的精子或上皮細胞中釋放,在調節各種生殖生理功能中起多種作用.本文綜述瞭ATP調節附睪上皮細胞陰離子分泌的信號通路,闡述瞭ATP對依賴上皮細胞的輸精管平滑肌收縮的調節機製,討論瞭ATP在男性生殖道中的功能和作用.
포외ATP제료능엄범작위신경체질외,환피인위시일충방분비혹자분비인자.ATP종남성생식도중적정자혹상피세포중석방,재조절각충생식생리공능중기다충작용.본문종술료ATP조절부고상피세포음리자분비적신호통로,천술료ATP대의뢰상피세포적수정관평활기수축적조절궤제,토론료ATP재남성생식도중적공능화작용.
In addition to its well established role as a neurotransmitter, extracellular ATP has been considered as a paracrine/autocrine factor, either released from sperm or epithelial cells, in the male reproductive tract and shown to play a versatile role in modulating various reproductive functions. This review summarizes the signal pathways through which ATP induces anion secretion by the epithelia of the epididymis, as well as its epithelium-dependent modulation of smooth muscle contraction of the vas deferens. Finally,the overall role of ATP in coordinating various reproductive events in the male genital tract is discussed.
