CAJ | 학술논문

目的：应用放免法查测豚鼠过敏性哮喘模型外周血和支气管肺泡灌洗液(BALF)白细胞介素(IL-6)水平，并探讨其与支气管肺泡灌洗液中炎症细胞的相关性。结果：发现外周血IL-6水平在哮喘组、地塞米松组、正常对照组之间无明显差异，而在BALF中IL-6水平哮喘组106.46±65.58pg/ml，显著高于正常对照组和地塞米松组，差异有显著性(P<0.05和P<0.01)，但哮喘组BALF中IL-6水平与嗜酸性细胞百分率之间无相关性(r=0.1508 P>0.05)。结论：IL-6参与了哮喘发病机制的调节。
목적：응용방면법사측돈서과민성효천모형외주혈화지기관폐포관세액(BALF)백세포개소(IL-6)수평，병탐토기여지기관폐포관세액중염증세포적상관성。결과：발현외주혈IL-6수평재효천조、지새미송조、정상대조조지간무명현차이，이재BALF중IL-6수평효천조106.46±65.58pg/ml，현저고우정상대조조화지새미송조，차이유현저성(P<0.05화P<0.01)，단효천조BALF중IL-6수평여기산성세포백분솔지간무상관성(r=0.1508 P>0.05)。결론：IL-6삼여료효천발병궤제적조절。
Objective:To investigate the level of IL-6 in the blood and BALF of asthmatic guniea pigs and the effect of dexamethasone. Methods:Guniea-pigs were divided into 3 groups: asthma group, dexamethascone-treatedgroup and control group,The IL - 6 was detected by RLA. Results:The eosinophil (Eos) percentage in BALF of asthmatic group was higher than other two groups, The IL- 6 level in blood has no difference in three groups. The IL- 6 level in BALF of asthmatic group was higher than dexamethasone- treated group and control group, there were no diffecence in BALF IL - 6 level between dexamathasone - treated group and control group. In asthma group, there were no relation between BALF IL- 6 level and the Eos percentage. Conclusions: IL- 6 may he involved in the development of allergic asthma.