CAJ | 학술논문

目的　通过动物实验观察肢体缺血再灌注损伤对肺组织形态学结构的影响。方法　110只Wistar大鼠随机分成正常对照、缺血2 h和缺血3 h三个组。缺血期和再灌注1，2，3，24 h取材行大体和组织形态学观察。结果　实验组肺水肿、肺泡隔增厚、毛细血管扩张、充血，大量中性白细胞浸润，局部肺不张和肺包膜细胞变性坏死。结论　肢体缺血再灌注可引起急性肺损伤。
목적　통과동물실험관찰지체결혈재관주손상대폐조직형태학결구적영향。방법　110지Wistar대서수궤분성정상대조、결혈2 h화결혈3 h삼개조。결혈기화재관주1，2，3，24 h취재행대체화조직형태학관찰。결과　실험조폐수종、폐포격증후、모세혈관확장、충혈，대량중성백세포침윤，국부폐불장화폐포막세포변성배사。결론　지체결혈재관주가인기급성폐손상。
Objective　To observe pathology change of the lung after lower limb ischemic reperfusion injury. Method　One hundred and ten rats were divided into control group, ischemia 2-hours and 3-hours groups. The histological assessment of the lung tissue were undertaken at 0, 1, 2, 3 and 24 hours after reperfusion. Result　It was found that pulmonary edema, microvascular congestion, infiltration of large amount of polymorphonuclear neutrophil (PMN) and partial pulmonary collapse were observed in experimental group at 3-hour ischemia, 1, 2, 3 and 24 hours after reperfusion. Conclusion　Reperfusion of acute ischemic extremites may produce structural change in lung.