CAJ | 학술논문

目的：探讨补气通络方对周围神经损伤的治疗效果，揭示其作用机理，为临床用药提供新的方法和途径。方法：实验通过清洁级Wistar大鼠48只，行右坐骨神经横形切断后即刻原位吻合术造模，制成神经损伤模型，造模成功后随机分成4组，每组12只。用补气通络胶囊剂和注射剂治疗作2个观察组，设立两个同期对照组：维生素B1＋B6的阳性对照组和空白对照组，经过造模后4、8、12周，每组随机抽取4只大鼠，取其双侧小腿三头肌称量湿重，以肌重及恢复程度作为观测指标，判断神经的修复情况。结果：补气通络方两个治疗组的小腿三头肌湿重及其恢复率比维生素B1＋B6组恢复快（P＜0．05）；比空白组差异非常显著（P＜0．01）；维生素B1＋B6组的恢复也明显快于空白组（P＜0．05）。结论：补气通络方对周围神经损伤后的恢复有促进作用，有临床开发利用价值。
목적：탐토보기통락방대주위신경손상적치료효과，게시기작용궤리，위림상용약제공신적방법화도경。방법：실험통과청길급Wistar대서48지，행우좌골신경횡형절단후즉각원위문합술조모，제성신경손상모형，조모성공후수궤분성4조，매조12지。용보기통락효낭제화주사제치료작2개관찰조，설립량개동기대조조：유생소B1＋B6적양성대조조화공백대조조，경과조모후4、8、12주，매조수궤추취4지대서，취기쌍측소퇴삼두기칭량습중，이기중급회복정도작위관측지표，판단신경적수복정황。결과：보기통락방량개치료조적소퇴삼두기습중급기회복솔비유생소B1＋B6조회복쾌（P＜0．05）；비공백조차이비상현저（P＜0．01）；유생소B1＋B6조적회복야명현쾌우공백조（P＜0．05）。결론：보기통락방대주위신경손상후적회복유촉진작용，유림상개발이용개치。
Purpose:To study the effect and mechanism of Buqi-Tongluo Prescription-a compound TCM drug including capsule and injection on resumption of rats's injured sciatic nerve and to discover some evidences for clinical treatment on peripheral nerve injury.Methods:48 clean Wistar rats models were made after all rats' right sciatic nerves were cut and then repaired with technique of neurorrhaphy.Then all injured rats were divided randomly into 4 groups and there were 12 rats in each group.All rats divided into Ⅰ group were treated with Buqi-Tongluo Capsule,Ⅱ group with Buqi-Tongluo Injection,Ⅲ group with Vitamin B1 & B6 Capsule,Ⅳ group with no drugs(Ⅳ).When having been treated for 4,8 and 12 weeks,4 rats at one time were picked out randomly from each group and had their wet weight of tricipital muscle (WW0TM)checked (after being killed) and compared with each other.Results:Both Ⅰ and Ⅱ group rats' WW0TM were bigger than those of Ⅲ group (P<0.05) and Ⅳ group (P<0.01);and Ⅲ group's WW0TM bigger than of Ⅳ group's also (P<0.05).Conclusions:Both Buqi-Tongluo capsule and injection could facilitate the regeneration of inured peripheral nerve and help injured nerve regain its function.