CAJ | 학술논문

-01)，ANF在短暂升高后降至治疗前水平，Scr无变化。结论 ACEI可能对CRF高血压患者肾内灌注压有影响，ANF动态改变可作为肾内灌注压变化的指标之一。ATRA对肾内灌注压影响小于ACEI。
-01)，ANF재단잠승고후강지치료전수평，Scr무변화。결론 ACEI가능대CRF고혈압환자신내관주압유영향，ANF동태개변가작위신내관주압변화적지표지일。ATRA대신내관주압영향소우ACEI。
Objective　To investigate the effects of angiotensin converting enzyme inhibitor (ACEI) and angiotensin II receptor antagonist (ATRA) on atrial natriuretic factor (ANF) and renin-angiotensin system (RAS) in patients with chronic renal failure (CRF).　Methods　The plasma angiotensin Ⅰ (AI), angiotensin Ⅱ (AII) and ANF levels were determined in 30 healthy volunteers and 40 patients with CRF after administration of losartan (Los) 50 mg once daily or fosinopril (Fos) 10 mg once daily in 0、4、8 and 12 weeks. Sit diastolic blood pressure (SiDBP) and blood urea nitrogen (BUN) and serum creatinine (SCr) were also measured at the same time. The data were analyzed by statistical software SPSS 7.0 .　Results　After 12 weeks, the levels of SiDBP were significantly decreased in both Los and Fos groups. In Fos group, aII was significantly inhibited, ANF and Scr were significantly increased (P<0.01). In Los group, aII was significantly increased (P<0.01), ANF reduced to normal level after it was increased at fourth week. SCr didn't increase.　Conclusion　There are significant effects of ACEI on intrarenal perfusion pressure. The change in ANF level may be used as a parameter for the effects. There are less effects of ATRA on intrarenal perfusion pressure than ACEI.