CAJ | 학술논문

目的　观察系统性红斑狼疮(systemic lupus erythematosus,SLE)中抗心磷脂抗体(anticardiolipin antibodies, ACA)的阳性率及与临床关系，以及免疫抑制剂对ACA滴度的影响。方法　用酶联免疫吸附法(ELISA)的ACAIg含量测定药盒，作血清ACA含量测定。对17例SLE患者入院及治疗3个月后行ACA滴度对比。结果 ACAIgG、ACAIgA、ACAIgM阳性率分别为：62.1%、52.9%、35.6%。ACAIgG、ACAIgM测定值与代表SLE活动性的病情积分呈正相关；ACAIgG、ACAIgA、 ACAIgM与补体C3呈负相关；ACAIgG与补体C4呈负相关。并发血栓时，ACAIgA增高；并发狼疮脑病时，ACAIgG、ACAIgM 测定值比无此并发症者明显增高。17例SLE患者治疗3月后，ACA滴度显著下降。结论 SLE的ACA测定值与病情活动性有关；并发血栓时，ACAIgA增高；并发狼疮脑病时，ACAIgG、ACAIgM测定值增高。经免疫抑制剂治疗3月后，ACA滴度显著下降。
목적　관찰계통성홍반랑창(systemic lupus erythematosus,SLE)중항심린지항체(anticardiolipin antibodies, ACA)적양성솔급여림상관계，이급면역억제제대ACA적도적영향。방법　용매련면역흡부법(ELISA)적ACAIg함량측정약 합，작혈청ACA함량측정。대17례SLE환자입원급치료3개월후행ACA적도대비。결과 ACAIgG、ACAIgA、ACAIgM양성 솔분별위：62.1%、52.9%、35.6%。ACAIgG、ACAIgM측정치여대표SLE활동성적병정적분정정상관；ACAIgG、ACAIgA、 ACAIgM여보체C3정부상관；ACAIgG여보체C4정부상관。병발혈전시，ACAIgA증고；병발랑창뇌병시，ACAIgG、ACAIgM 측정치비무차병발증자명현증고。17례SLE환자치료3월후，ACA적도현저하강。결론 SLE적ACA측정치여병정활동성유 관；병발혈전시，ACAIgA증고；병발랑창뇌병시，ACAIgG、ACAIgM측정치증고。경면역억제제치료3월후，ACA적도현저하강。
Objective To observe the prevalence and clinical association of anticardiolipin antibodies(ACA)and the in- fluence of immunosuppressive therapy on titers of ACA in systemic lupus erythematosus (SLE). Methods ACA(IgG, IgA, IgM)was measured by enzyme-linked immunosorbent assay(ELISA)in the serum sample of 87 patients of SLE. 17 cases of SLE had been tested on admission and 3 months after treatment with immunosuppressive therapy . Results The prevalence of ACAIgG,ACAIgA ,ACAIgM was respectively 62.1%,52.9%,35.6% in SLE. The titers of ACAIgG and ACAIgM were sig- nificantly and positively correlated with disease activity;ACAIgG,ACAIgA and ACAIgM were significantly and negatively correlated with complement C3 ,ACAIgG was significantly and negatively correlated with complement C4. With thrombosis,the titers of ACAIgA were higher than those without thrombosis. Among the patients with central nervous system involvement (CNS-SLE),ACAIgG and ACAIgM titers were significantly higher than those without CNS-SLE. There is a significant differ- ence between the means of ACA titers of 17 SLE on admission and three months after treatment. Conclusions ACA titers were positively correlated with disease activity. With thrombosis, the titers of ACAIgA were higher. With CNS-SLE,ACAIgG and ACAIgM titers were higher. Immunosuppressive therapy decreases the ACA titers of SLE.